The perlecan fragment LG3 is a novel regulator of obliterative remodeling associated with allograft vascular rejection.
Research Centre, Centre Hospitalier de l'Université de Montréal, Hôpital Notre Dame and Université de Montréal, Montréal, Quebec, Canada.
Endothelial apoptosis is increased in association with acute and chronic vascular rejection (VR) of solid allografts. Apoptotic endothelial cells (EC) release LG3, a C-terminal fragment of perlecan of potential importance in vascular remodeling and neointima formation.
Circ. Res. 2012;110(1):94-104.
Pubmed ID: 22076637