Publications
IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.
The Nuclear Pore Complex and mRNA Export in Cancer.Cancers (Basel) 2020-12-25;13(1).
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling.Cell 2020-12-23;183(7):1813-1825.e18.
Signal Transduction Profiling of Angiotensin II Type 1 Receptor With Mutations Associated to Atrial Fibrillation in Humans.Front Pharmacol 2020-12-22;11:600132.
MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus.Blood 2020-12-10;136(24):2764-2773.
Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H3 and H4 receptors.Bioorg Med Chem 2020-12-08;30:115924.
A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients.Cell Death Discov 2020-12-08;6(1):141.
A Roadmap Toward the Definition of Actionable Tumor-Specific Antigens.Front Immunol 2020-12-03;11:583287.
H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone.Cancer Discov 2020-12-01;10(12):1968-1987.
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis.Biochim Biophys Acta Mol Cell Res 2020-12-01;1867(12):118849.
Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors.Eur J Haematol 2020-12-01;105(6):808-811.
Beta-arrestins operate an on/off control switch for focal adhesion kinase activity.Cell Mol Life Sci 2020-12-01;77(24):5259-5279.
The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects.Commun Biol 2020-11-27;3(1):719.
Proteomics of Herpes Simplex Virus Type 1 Nuclear Capsids.J Virol 2020-11-25;95(4):e01842-19.
ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species.Cell Chem Biol 2020-11-19;27(11):1452.
Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASγ.Biochim Biophys Acta Mol Cell Res 2020-11-13;1868(2):118908.
Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.ACS Med Chem Lett 2020-11-12;11(11):2261-2267.
Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.bioRxiv 2020-11-06.
Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.PLoS Genet 2020-11-02;16(11):e1009184.
STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity.J Cell Biol 2020-11-02;219(11).
Functional characterization of a PROTAC directed against BRAF mutant V600E.Nat Chem Biol 2020-11-01;16(11):1170-1178.
RAS GTPase signalling to alternative effector pathways.Biochem Soc Trans 2020-10-30;48(5):2241-2252.
The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts.Proc Natl Acad Sci U S A 2020-10-27;117(43):26773-26783.
Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.Sci Rep 2020-10-15;10(1):17395.
Catechin from Burkea africana Hook. Exhibits in vitro inhibition of human telomerase activity.Nat Prod Res 2020-10-14:1-5.
RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway.Sci Signal 2020-10-13;13(653).
Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study.Front Physiol 2020-10-09;11:564140.
Targeting copper metabolism to defeat KRAS-driven colorectal cancer.Mol Cell Oncol 2020-10-07;7(6):1822123.
Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age.Aging Cell 2020-10-07:e13245.
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality.J. Cell Biol. 2020-10-05;219(10).
ERK signalling: a master regulator of cell behaviour, life and fate.Nat Rev Mol Cell Biol 2020-10-01;21(10):607-632.
Major multilevel molecular divergence between THP-1 cells from different biorepositories.Int. J. Cancer 2020-10-01;147(7):2000-2006.
Newly diagnosed multiple myeloma patients treated with tandem auto-allogeneic stem cell transplant have better overall survival with similar outcomes at time of relapse compared to patients who received autologous transplant only.Clin Transplant 2020-09-27:e14099.
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.Cell Rep 2020-09-22;32(12):108170.
Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.EMBO J 2020-09-16:e103420.
The Origin and Immune Recognition of Tumor-Specific Antigens.Cancers (Basel) 2020-09-12;12(9).
G1/S transcription factors assemble in increasing numbers of discrete clusters through G1 phase.J. Cell Biol. 2020-09-07;219(9).
Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.Mol Cell 2020-09-03;79(5):846-856.e8.
Agonist-induced formation of unproductive receptor-G12 complexes.Proc Natl Acad Sci U S A 2020-09-01;117(35):21723-21730.
IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells.J. Immunol. 2020-09-01;205(5):1268-1280.
Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.Cancer Discov 2020-09-01;10(9):1312-1329.
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer.Nat Commun 2020-08-21;11(1):4205.
An ErbB2 splice variant lacking exon 16 drives lung carcinoma.Proc. Natl. Acad. Sci. U.S.A. 2020-08-18;117(33):20139-20148.
RNA-Puzzles Round IV: 3D structure predictions of four ribozymes and two aptamers.RNA 2020-08-01;26(8):982-995.
BMP signaling is essential for sustaining proximo-distal progression in regenerating axolotl limbs.Development 2020-07-31;147(14).
Apoptotic exosome-like vesicles regulate endothelial gene expression, inflammatory signaling, and function through the NF-κB signaling pathway.Sci Rep 2020-07-28;10(1):12562.
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Nat Commun 2020-07-24;11(1):3701.
Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G-protein-coupled receptors.J. Biol. Chem. 2020-07-24;295(30):10153-10167.
Cholesterol as an Endogenous Ligand of ERRα Promotes ERRα-Mediated Cellular Proliferation and Metabolic Target Gene Expression in Breast Cancer Cells.Cells 2020-07-23;9(8).
Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma Nature Cancer 2020-07-20;1(8):840-854.
Survey Says: "COVID-19 Lockdown Hits Young Faculty and Clinical Trials".Stem Cell Reports 2020-07-14;15(1):1-5.
Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.Nat Commun 2020-07-10;11(1):3464.
Extending the Comprehensiveness of Immunopeptidome Analyses Using Isobaric Peptide Labeling.Anal. Chem. 2020-07-07;92(13):9194-9204.
Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors.iScience 2020-07-01;23(7):101335.
Factorized embeddings learns rich and biologically meaningful embedding spaces using factorized tensor decomposition.Bioinformatics 2020-07-01;36(Supplement_1):i417-i426.
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.Nat. Cell Biol. 2020-07-01;22(7):803-814.
Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy in humans and mice.Blood 2020-06-18;135(25):2235-2251.
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Cell 2020-06-11;181(6):1329-1345.e24.
The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery.RNA Biol 2020-06-04:1-13.
From transient recognition to efficient silencing: a RISCky business.Nat. Struct. Mol. Biol. 2020-06-01;27(6):519-520.
Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR.Sci Rep 2020-05-29;10(1):8779.
NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.Cell Rep 2020-05-19;31(7):107660.
Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.Am. J. Respir. Crit. Care Med. 2020-05-15;201(10):1263-1276.
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.Nat Commun 2020-05-14;11(1):2396.
Interferon, restriction factors and SUMO pathways.Cytokine Growth Factor Rev. 2020-05-08.
A targetable cue in T-cell malignancy.Blood 2020-05-07;135(19):1616-1617.
Interplay of Ubiquitin-Like Modifiers Following Arsenic Trioxide Treatment.J. Proteome Res. 2020-05-01;19(5):1999-2010.
Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.Genome Med 2020-04-28;12(1):40.
Controversies around the function of LARP1.RNA Biol 2020-04-17:1-11.
Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.Elife 2020-04-16;9.
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.Genetics 2020-04-15;214(4):1103-1120.
The miR-185/PAK6 Axis Predicts Therapy Response and Regulates Survival of Drug-Resistant Leukemic Stem Cells in CML.Blood 2020-04-09.
Structural Insight into G Protein-Coupled Receptor Signaling Efficacy and Bias between Gs and β-Arrestin.ACS Pharmacol Transl Sci 2020-04-09;2(3):148-154.
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.Leukemia 2020-04-03.
MAPDP: A Cloud-Based Computational Platform for Immunopeptidomics Analyses.J. Proteome Res. 2020-04-03;19(4):1873-1881.
Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer.Cancer Immunol Res 2020-04-03;8(4):544-555.
Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.Hum. Mol. Genet. 2020-03-31;29(5):766-784.
Extracellular vesicles derived from injured vascular tissue promote the formation of tertiary lymphoid structures in vascular allografts.Am. J. Transplant. 2020-03-20;20(3):726-738.
Cross-talk between SUMOylation and ISGylation in response to interferon.Cytokine 2020-02-17;129:155025.
Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility.Nat Commun 2020-02-14;11(1):834.
High frequency of germline RUNX1 mutations in RUNX1 mutated AML patients.Blood 2020-02-13.
Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration.Front Immunol 2020-02-11;10:3118.
Editorial overview: The instability of the cancer genome: it starts at the end.Curr. Opin. Genet. Dev. 2020-02-01;60:iii-vi.
Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.Lancet Haematol 2020-01-31;7(2):e134-e145.
F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.Dev. Cell 2020-01-29;52(2):210-222.e7.
Kinesin Kif2C in regulation of DNA double strand break dynamics and repair.Elife 2020-01-21;9.
The Genomic Landscape of Antigenic Targets for T Cell-Based Leukemia Immunotherapy.Front Immunol 2020-01-13;10:2934.
Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment.JACC Basic Transl Sci 2020-01-09;4(8):905-920.
Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.Mol. Cell Proteomics 2020-01-02;19(1):50-64.
A transcriptome-based approach to identify functional modules within and across primary human immune cells.PLoS ONE 2020-01-01;15(5):e0233543.
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