IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

PSMB11 Orchestrates the Development of CD4 and CD8 Thymocytes via Regulation of Gene Expression in Cortical Thymic Epithelial Cells.Apavaloaei A, Brochu S, Dong M, Rouette A, Hardy MP, Villafano G, Murata S, Melichar HJ, Perreault CJ. Immunol. 2018-12-19.

Noncoding regions are the main source of targetable tumor-specific antigens.Laumont CM, Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault CSci Transl Med 2018-12-05;10(470).

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann CSci Signal 2018-12-04;11(559).

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SASci Signal 2018-12-04;11(559).

PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila.Mehsen H, Boudreau V, Garrido D, Bourouh M, Larouche M, Maddox PS, Swan A, Archambault VJ. Cell Biol. 2018-12-03;217(12):4106-4123.

Detecting short RNA sequences of pathogens.Bouilly DNat Nanotechnol 2018-12-01;13(12):1094-1096.

Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.Yao C, Wang C, Li Y, Zavortink M, Archambault V, Girton J, Johansen KM, Johansen JPLoS ONE 2018-11-28;13(11):e0208022.

The Impact of Post-transcriptional Control: Better Living Through RNA Regulons.Culjkovic-Kraljacic B, Borden KLBFront Genet 2018-11-05;9:512.

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BKNat. Chem. Biol. 2018-11-01;14(11):1059-1066.

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.Hamoud N, Tran V, Aimi T, Kakegawa W, Lahaie S, Thibault MP, Pelletier A, Wong GW, Kim IS, Kania A, Yuzaki M, Bouvier M, Côté JFNat Commun 2018-10-26;9(1):4470.

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