IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.Schönegge AM, Gallion J, Picard LP, Wilkins AD, Le Gouill C, Audet M, Stallaert W, Lohse MJ, Kimmel M, Lichtarge O, Bouvier MNat Commun 2017-12-18;8(1):2169.

Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells during Caenorhabditis elegans embryogenesis.Goupil E, Amini R, Hall DH, Labbé JCMol. Biol. Cell 2017-12-15;28(26):3789-3800.

Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit RMol. Cell. Biol. 2017-12-15;37(24).

Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus.Dumont-Lagacé M, Gerbe H, Daouda T, Laverdure JP, Brochu S, Lemieux S, Gagnon E, Perreault CFront Immunol 2017-12-05;8:1717.

Identification of novel biomarkers for MLL-translocated acute myeloid leukemia.Lagacé K, Barabé F, Hébert J, Cellot S, Wilhelm BTExp. Hematol. 2017-12-01;56:58-63.

Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress.St-Pierre C, Morgand E, Benhammadi M, Rouette A, Hardy MP, Gaboury L, Perreault CCell Rep 2017-11-28;21(9):2558-2570.

Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry.Kachaner D, Garrido D, Mehsen H, Normandin K, Lavoie H, Archambault VNat Commun 2017-11-22;8(1):1701.

H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations.Lehnertz B, Zhang YW, Boivin I, Mayotte N, Tomellini E, Chagraoui J, Lavallée VP, Hébert J, Sauvageau GBlood 2017-11-16;130(20):2204-2214.

Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny Y, Lemieux S, Marinier A, Hébert J, Sauvageau GClin. Cancer Res. 2017-11-15;23(22):6969-6981.

Synthetic human leukemia models: towards precision medicine.Cellot S, Wilhelm BT, Barabé FOncotarget 2017-11-14;8(57):96480-96481.

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