IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.
Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.Nat Commun 2017-12-18;8(1):2169.
Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells during Caenorhabditis elegans embryogenesis.Mol. Biol. Cell 2017-12-15;28(26):3789-3800.
Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.Mol. Cell. Biol. 2017-12-15;37(24).
Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus.Front Immunol 2017-12-05;8:1717.
Identification of novel biomarkers for MLL-translocated acute myeloid leukemia.Exp. Hematol. 2017-12-01;56:58-63.
Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress.Cell Rep 2017-11-28;21(9):2558-2570.
Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry.Nat Commun 2017-11-22;8(1):1701.
H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations.Blood 2017-11-16;130(20):2204-2214.
Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.Clin. Cancer Res. 2017-11-15;23(22):6969-6981.
Synthetic human leukemia models: towards precision medicine.Oncotarget 2017-11-14;8(57):96480-96481.