Publications
IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.
Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.Nat Commun 2017-12-18;8(1):2169.
Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells during Caenorhabditis elegans embryogenesis.Mol. Biol. Cell 2017-12-15;28(26):3789-3800.
Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.Mol. Cell. Biol. 2017-12-15;37(24).
Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus.Front Immunol 2017-12-05;8:1717.
Identification of novel biomarkers for MLL-translocated acute myeloid leukemia.Exp. Hematol. 2017-12-01;56:58-63.
Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress.Cell Rep 2017-11-28;21(9):2558-2570.
Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry.Nat Commun 2017-11-22;8(1):1701.
H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations.Blood 2017-11-16;130(20):2204-2214.
Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.Clin. Cancer Res. 2017-11-15;23(22):6969-6981.
Synthetic human leukemia models: towards precision medicine.Oncotarget 2017-11-14;8(57):96480-96481.
Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential.Front Pharmacol 2017-11-14;8:825.
The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity.Elife 2017-11-07;6.
Identification of cross talk between SUMOylation and ubiquitylation using a sequential peptide immunopurification approach.Nat Protoc 2017-11-01;12(11):2342-2358.
Study of Methylene Blue Ototoxicity in the Guinea Pig.J Clin Med Res 2017-11-01;9(11):900-906.
Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance.Immunol. Rev. 2017-11-01;280(1):165-174.
WD40 repeat domain proteins: a novel target class?Nat Rev Drug Discov 2017-11-01;16(11):773-786.
PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers.Mol. Cancer Ther. 2017-11-01;16(11):2528-2542.
UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis.FASEB J. 2017-11-01;31(11):5012-5018.
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.Nat Commun 2017-10-31;8(1):1211.
Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.Nat Commun 2017-10-23;8(1):1099.
Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer.Cell Rep 2017-10-17;21(3):798-812.
HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma.Oncotarget 2017-09-19;8(41):69559-69576.
Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy.Sci Rep 2017-09-19;7(1):11903.
Single Electron Transistor with Single Aromatic Ring Molecule Covalently Connected to Graphene Nanogaps.Nano Lett. 2017-09-13;17(9):5335-5341.
Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats.Proc. Natl. Acad. Sci. U.S.A. 2017-08-22;114(34):9044-9049.
An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation.J. Immunol. 2017-08-15;199(4):1490-1504.
MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets.Nucleic Acids Res. 2017-07-27;45(13):e122.
Mammographic density, blood telomere length and lipid peroxidation.Sci Rep 2017-07-19;7(1):5803.
Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.Mol. Cell 2017-07-13.
Presence of diabetes autoantigens in extracellular vesicles derived from human islets.Sci Rep 2017-07-10;7(1):5000.
CLMSVault: A Software Suite for Protein Cross-Linking Mass-Spectrometry Data Analysis and Visualization.J. Proteome Res. 2017-07-07;16(7):2645-2652.
RNA-MoIP: prediction of RNA secondary structure and local 3D motifs from sequence data.Nucleic Acids Res. 2017-07-03;45(W1):W440-W444.
AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.Nat. Cell Biol. 2017-07-01;19(7):844-855.
EPCR expression marks UM171-expanded CD34(+) cord blood stem cells.Blood 2017-06-22;129(25):3344-3351.
Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.Bioconjug. Chem. 2017-06-21;28(6):1677-1683.
Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators.Cell Cycle 2017-06-18;16(12):1220-1224.
A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.RNA 2017-06-01;23(6):927-937.
Mining Cancer Transcriptomes: Bioinformatic Tools and the Remaining Challenges.Mol Diagn Ther 2017-06-01;21(3):249-258.
Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.BMC Cancer 2017-05-22;17(1):356.
Actin cortex architecture regulates cell surface tension.Nat. Cell Biol. 2017-05-22.
Synthetic Genomics: Rewriting the Genome Chromosome by Chromosome.Mol. Cell 2017-05-18;66(4):441-443.
Electrostatic melting in a single-molecule field-effect transistor with applications in genomic identification.Nat Commun 2017-05-18;8:15450.
Defining the role of the RSK isoforms in cancer.Semin. Cancer Biol. 2017-05-02.
SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism.Nat. Genet. 2017-05-01;49(5):753-764.
Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca(2+) in Nonexcitable Cells.Mol. Pharmacol. 2017-05-01;91(5):533-544.
Machine Learning of Global Phosphoproteomic Profiles Enables Discrimination of Direct versus Indirect Kinase Substrates.Mol. Cell Proteomics 2017-05-01;16(5):786-798.
Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling.Hum. Mutat. 2017-05-01;38(5):569-580.
Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity.Mol. Cell. Biol. 2017-05-01;37(9).
RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.RNA 2017-05-01;23(5):655-672.
MCM2: An alternative to Ki-67 for measuring breast cancer cell proliferation.Mod. Pathol. 2017-05-01;30(5):682-697.
Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target.Leukemia 2017-05-01;31(5):1166-1176.
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.Nat Commun 2017-04-18;8:15054.
Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription.Nucleic Acids Res. 2017-04-07;45(6):3017-3030.
DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation.PLoS Genet. 2017-04-01;13(4):e1006738.
Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.Mol. Cell Proteomics 2017-04-01;16(4):663-679.
Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function.Mol. Pharmacol. 2017-04-01;91(4):287-295.
Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling.Mol. Cell. Biol. 2017-04-01;37(7).
The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance.Exp. Hematol. 2017-04-01;48:58-71.e15.
Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.J. Med. Chem. 2017-03-22.
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.Mol. Syst. Biol. 2017-03-15;13(3):918.
Multimodal and Polymorphic Interactions between Anillin and Actin: Their Implications for Cytokinesis.J. Mol. Biol. 2017-03-10;429(5):715-731.
Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.Proc. Natl. Acad. Sci. U.S.A. 2017-03-07;114(10):2562-2567.
Studying Dynamic Plasma Membrane Binding of TCR-CD3 Chains During Immunological Synapse Formation Using Donor-Quenching FRET and FLIM-FRET.Methods Mol. Biol. 2017-03-03;1584:259-289.
Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?Cell Stem Cell 2017-03-02;20(3):300-301.
Non-autonomous role of Cdc42 in cell-cell communication during collective migration.Dev. Biol. 2017-03-01;423(1):12-18.
A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.Blood Cancer J 2017-02-17;7(2):e529.
Major vs minor histocompatibility antigens.Blood 2017-02-09;129(6):664-666.
KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents.J. Neurosci. 2017-02-01;37(5):1162-1175.
Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis.Mol. Cell. Biol. 2017-02-01;37(3).
Distinct signaling programs control human hematopoietic stem cell survival and proliferation.Blood 2017-01-19;129(3):307-318.
Uncovering the SUMOylation and ubiquitylation crosstalk in human cells using sequential peptide immunopurification.Nat Commun 2017-01-18;8:14109.
The BioC-BioGRID corpus: full text articles annotated for curation of protein-protein and genetic interactions.Database (Oxford) 2017-01-10;2017.
Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.Mol. Cell 2017-01-05;65(1):78-90.
Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.Sci Transl Med 2017-01-04;9(371).
The BioGRID interaction database: 2017 update.Nucleic Acids Res. 2017-01-04;45(D1):D369-D379.
An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF(Cdc4) ubiquitin ligase.Nat Commun 2017-01-03;8:13943.
Isolation of Mouse Embryonic Stem Cell Lines in the Study of ERK1/2 MAP Kinase Signaling.Methods Mol. Biol. 2017-01-01;1487:243-253.
How Genetics Has Helped Piece Together the MAPK Signaling Pathway.Methods Mol. Biol. 2017-01-01;1487:1-21.
Older adults with heart failure treated with carvedilol, bisoprolol, or metoprolol tartrate: risk of mortality.Pharmacoepidemiol Drug Saf 2017-01-01;26(1):81-90.
Production and Purification of Antibodies Against Histone Modifications.Methods Mol. Biol. 2017-01-01;1528:149-164.
Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.Dev. Biol. 2017-01-01;421(1):16-26.
Inhibition of RAS function through targeting an allosteric regulatory site.Nat. Chem. Biol. 2017-01-01;13(1):62-68.
Antiestrogens: structure-activity relationships and use in breast cancer treatment.J. Mol. Endocrinol. 2017-01-01;58(1):R15-R31.
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