Publications
IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.
Checkpoint adaptation: Keeping Cdc5 in the T-loop.Cell Cycle 2016-12-16;15(24):3339-3340.
Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection.Nucleic Acids Res. 2016-12-15;44(22):10571-10587.
Improvement of Quantitative Measurements in Multiplex Proteomics Using High-Field Asymmetric Waveform Spectrometry.J. Proteome Res. 2016-12-02;15(12):4653-4665.
MHC class I-associated peptides derive from selective regions of the human genome.J. Clin. Invest. 2016-12-01;126(12):4690-4701.
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.J. Clin. Invest. 2016-12-01;126(12):4569-4584.
Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer.PLoS ONE 2016-11-30;11(11):e0166731.
Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism.Sci Data 2016-11-22;3:160095.
Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay.Sci Rep 2016-11-22;5:37581.
Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function.Cell Chem Biol 2016-11-17;23(11):1383-1394.
Structural dynamics control the MicroRNA maturation pathway.Nucleic Acids Res. 2016-11-16;44(20):9956-9964.
Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.Cell Rep 2016-11-08;17(7):1755-1763.
A Pluridimensional View of Biased Agonism.Mol. Pharmacol. 2016-11-01;90(5):587-595.
Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions.Nat Nanotechnol 2016-11-01;11(11):941-947.
Positive regulation of the Candida albicans multidrug efflux pump Cdr1p function by phosphorylation of its N-terminal extension.J. Antimicrob. Chemother. 2016-11-01;71(11):3125-3134.
ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.Oncogene 2016-10-27;35(43):5692-5698.
Introduction to the HUPO 2015 Special Issue.J Proteomics 2016-10-21;149:1-2.
Data Independent Acquisition analysis in ProHits 4.0.J Proteomics 2016-10-21;149:64-68.
The RTA3 Gene, Encoding a Putative Lipid Translocase, Influences the Susceptibility of Candida albicans to Fluconazole.Antimicrob. Agents Chemother. 2016-10-01;60(10):6060-6.
Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons.BMC Genomics 2016-09-26;17(1):754.
Exploring Alternative RNA Structure Sets Using MC-Flashfold and db2cm.Methods Mol. Biol. 2016-09-25;1490:237-51.
Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers.Sci Rep 2016-09-23;6:34019.
First case report of an adrenocortical carcinoma caused by a BRCA2 mutation.Medicine (Baltimore) 2016-09-01;95(36):e4756.
BioCreative V BioC track overview: collaborative biocurator assistant task for BioGRID.Database (Oxford) 2016-09-01;2016:baw121.
Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress.Am. J. Obstet. Gynecol. 2016-09-01;215(3):384.e1-384.e89.
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region.Nature 2016-08-25;536(7617):484-7.
ERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules.J. Immunol. 2016-08-15;197(4):1035-43.
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.Cell 2016-08-11;166(4):907-19.
The eukaryotic translation initiation factor eIF4E wears a "cap" for many occasions.Translation (Austin) 2016-08-10;4(2):e1220899.
The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.PLoS Biol. 2016-08-01;14(8):e1002539.
Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.Sci Signal 2016-07-26;9(438):ra75.
Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).J. Biol. Chem. 2016-07-22;291(30):15641-52.
Polo kinase Cdc5 associates with centromeres to facilitate the removal of centromeric cohesin during mitosis.Mol. Biol. Cell 2016-07-15;27(14):2286-300.
Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation.Cell 2016-07-14;166(2):314-27.
Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.Proc. Natl. Acad. Sci. U.S.A. 2016-07-12;113(28):7786-91.
Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET.Nat Commun 2016-07-11;7:12178.
Unraveling Site-Specific and Combinatorial Histone Modifications Using High-Resolution Mass Spectrometry in Histone Deacetylase Mutants of Fission Yeast.J. Proteome Res. 2016-07-01;15(7):2132-42.
Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations.Leukemia 2016-07-01;30(7):1621-4.
Redundancy in the World of MAP Kinases: All for One.Front Cell Dev Biol 2016-06-27;4:67.
Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway.Cell Cycle 2016-06-17;15(12):1631-42.
Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.Blood 2016-06-16;127(24):3054-61.
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.Cancer Cell 2016-06-13;29(6):859-73.
Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells.Sci Rep 2016-06-07;6:27379.
Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets.Blood Cancer J 2016-06-03;6(6):e431.
Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile.J. Immunol. 2016-06-01;196(11):4760-70.
Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers.Leukemia 2016-06-01;30(6):1344-54.
Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.J. Med. Chem. 2016-05-26;59(10):4697-710.
SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells.PLoS ONE 2016-05-25;11(5):e0156365.
RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature.Blood 2016-05-19;127(20):2498-501.
Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.Proc. Natl. Acad. Sci. U.S.A. 2016-05-10;113(19):5263-8.
Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells.Nature 2016-04-28;532(7600):508-11.
Myelopoiesis.Encyclopedia of Immunobiology 2016-04-27;1:26-37.
GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.Blood 2016-04-21;127(16):2018-27.
Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.Proc. Natl. Acad. Sci. U.S.A. 2016-04-19;113(16):4524-9.
Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.Nucleic Acids Res. 2016-04-07;44(6):2706-26.
Galectin signatures contribute to the heterogeneity of breast cancer and provide new prognostic information and therapeutic targets.Oncotarget 2016-04-05;7(14):18183-203.
Econazole imprinted textiles with antifungal activity.Eur J Pharm Biopharm 2016-04-01;101:137-44.
Cellular localisation of the kinin B1R in the pancreas of streptozotocin-treated rat and the anti-diabetic effect of the antagonist SSR240612.Biol. Chem. 2016-04-01;397(4):323-36.
Favorable long-term outcome of patients with multiple myeloma using a frontline tandem approach with autologous and non-myeloablative allogeneic transplantation.Bone Marrow Transplant. 2016-04-01;51(4):529-35.
Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.Proc. Natl. Acad. Sci. U.S.A. 2016-03-29;113(13):3527-32.
ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer.Oncotarget 2016-03-29;7(13):15811-27.
Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14.J. Biol. Chem. 2016-03-25;291(13):7156-70.
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.Mitochondrion 2016-02-23.
SCL/TAL1 in Hematopoiesis and Cellular Reprogramming.Curr. Top. Dev. Biol. 2016-02-18;118:163-204.
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.Blood 2016-02-18;127(7):858-68.
Centrosome-Dependent Bypass of the DNA Damage Checkpoint by the Polo Kinase Cdc5.Cell Rep 2016-02-16;14(6):1422-1434.
Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle.Cell Cycle 2016-02-16;15(4):528-39.
Bigger Isn't Always Better: Cell Size and the Spindle Assembly Checkpoint.Dev. Cell 2016-02-08;36(3):244-6.
The LMO2 oncogene regulates DNA replication in hematopoietic cells.Proc. Natl. Acad. Sci. U.S.A. 2016-02-02;113(5):1393-8.
In vitro assay to determine SUMOylation sites on protein substrates.Nat Protoc 2016-02-01;11(2):387-97.
Lifelong leukocyte telomere dynamics and survival in a free-living mammal.Aging Cell 2016-02-01;15(1):140-8.
Cellular and subcellular context determine outputs from signaling biosensors.Methods Cell Biol. 2016-01-29;132:319-37.
Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells.Blood 2016-01-07;127(1):87-90.
pyGeno: A Python package for precision medicine and proteogenomics.F1000Res 2016-01-01;5:381.
Cascade: an RNA-seq visualization tool for cancer genomics.BMC Genomics 2016-01-01;17(1):75.
BioGRID: A Resource for Studying Biological Interactions in Yeast.Cold Spring Harb Protoc 2016-01-01;2016(1):pdb.top080754.
Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions.Cold Spring Harb Protoc 2016-01-01;2016(1):pdb.prot088880.
Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.Nat Commun 2016-01-01;7:10238.
Placental Underperfusion in a Rat Model of Intrauterine Growth Restriction Induced by a Reduced Plasma Volume Expansion.PLoS ONE 2016-01-01;11(1):e0145982.
Follow IRIC: