IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Checkpoint adaptation: Keeping Cdc5 in the T-loop.Serrano D, D'Amours DCell Cycle 2016-12-16;15(24):3339-3340.

Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection.Bouttier M, Laperriere D, Memari B, Mangiapane J, Fiore A, Mitchell E, Verway M, Behr MA, Sladek R, Barreiro LB, Mader S, White JHNucleic Acids Res. 2016-12-15;44(22):10571-10587.

Improvement of Quantitative Measurements in Multiplex Proteomics Using High-Field Asymmetric Waveform Spectrometry.Pfammatter S, Bonneil E, Thibault PJ. Proteome Res. 2016-12-02;15(12):4653-4665.

MHC class I-associated peptides derive from selective regions of the human genome.Pearson H, Daouda T, Granados DP, Durette C, Bonneil E, Courcelles M, Rodenbrock A, Laverdure JP, Côté C, Mader S, Lemieux S, Thibault P, Perreault CJ. Clin. Invest. 2016-12-01;126(12):4690-4701.

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok BH, Roux PP, Hoang TJ. Clin. Invest. 2016-12-01;126(12):4569-4584.

Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer.Grosset AA, Poirier F, Gaboury L, St-Pierre YPLoS ONE 2016-11-30;11(11):e0166731.

Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism.Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers MSci Data 2016-11-22;3:160095.

Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay.Normandin K, Lavallée JF, Futter M, Beautrait A, Duchaine J, Guiral S, Marinier A, Archambault VSci Rep 2016-11-22;5:37581.

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function.Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GDCell Chem Biol 2016-11-17;23(11):1383-1394.

Structural dynamics control the MicroRNA maturation pathway.Dallaire P, Tan H, Szulwach K, Ma C, Jin P, Major FNucleic Acids Res. 2016-11-16;44(20):9956-9964.

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