IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning.Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers MCell Syst 2015-12-23;1(6):383-95.

The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection.Dieudé M, Bell C, Turgeon J, Beillevaire D, Pomerleau L, Yang B, Hamelin K, Qi S, Pallet N, Béland C, Dhahri W, Cailhier JF, Rousseau M, Duchez AC, Lévesque T, Lau A, Rondeau C, Gingras D, Muruve D, Rivard A, Cardinal H, Perreault C, Desjardins M, Boilard É, Thibault P, Hébert MJSci Transl Med 2015-12-16;7(318):318ra200.

Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids.Mendoza-Sanchez R, Cotnoir-White D, Kulpa J, Jutras I, Pottel J, Moitessier N, Mader S, Gleason JLBioorg. Med. Chem. 2015-12-15;23(24):7597-606.

DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans.Narbonne P, Maddox PS, Labbé JCDevelopment 2015-12-15;142(24):4230-41.

The experimental power of FR900359 to study Gq-regulated biological processes.Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis ENat Commun 2015-12-14;6:10156.

The lighthouse at the end of the chromosome.Benslimane Y, Harrington LF1000Res 2015-12-11;4.

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.Robbins N, Spitzer M, Yu T, Cerone RP, Averette AK, Bahn YS, Heitman J, Sheppard DC, Tyers M, Wright GDCell Rep 2015-11-17;13(7):1481-92.

Association of Treatment with Carvedilol, Bisoprolol and Metoprolol on the Risk of Mortality and Hospital Admission Among Older Adults with Heart Failure.Perreault S, de Denus S, White M, White-Guay B, Bouvier M, Dorais M, Dubé M, Rouleau J, Tardif J, Jenna S, Haibe-Kains B, Leduc R, Deblois DValue Health 2015-11-01;18(7):A379.

Enhancement of mass spectrometry performance for proteomic analyses using high-field asymmetric waveform ion mobility spectrometry (FAIMS).Bonneil E, Pfammatter S, Thibault PJ Mass Spectrom 2015-11-01;50(11):1181-95.

Discovery of protein acetylation patterns by deconvolution of peptide isomer mass spectra.Abshiru N, Caron-Lizotte O, Rajan RE, Jamai A, Pomies C, Verreault A, Thibault PNat Commun 2015-10-15;6:8648.

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