IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Development and Characterization of Pepducins as Gs-biased Allosteric Agonists.Carr R, Du Y, Quoyer J, Panettieri RA, Janz JM, Bouvier M, Kobilka BK, Benovic JLJ. Biol. Chem. 2014-12-26;289(52):35668-84.

SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells.Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang TPLoS Genet. 2014-12-18;10(12):e1004768.

When Will Resistance Be Futile?Borden KLCancer Res. 2014-12-15;74(24):7175-7180.

Bloody signals: From birth to disease and death.Trompouki E, King KY, Will B, Lessard J, Flores-Figueroa E, Kokkaliaris KD, Bowman TExp. Hematol. 2014-12-01;42(12):989-94.

The yeast polo kinase cdc5 regulates the shape of the mitotic nucleus.Walters AD, May CK, Dauster ES, Cinquin BP, Smith EA, Robellet X, D'Amours D, Larabell CA, Cohen-Fix OCurr. Biol. 2014-12-01;24(23):2861-7.

Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.Der Sarkissian S, Cailhier JF, Borie M, Stevens LM, Gaboury L, Mansour S, Hamet P, Noiseux NBr. J. Pharmacol. 2014-12-01;171(23):5265-79.

Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation.Fairlie J, Harrington LDNA Repair (Amst.) 2014-11-24;25C:54-59.

Proteomic-Coupled-Network Analysis of T877A-Androgen Receptor Interactomes Can Predict Clinical Prostate Cancer Outcomes between White (Non-Hispanic) and African-American Groups.Zaman N, Giannopoulos PN, Chowdhury S, Bonneil E, Thibault P, Wang E, Trifiro M, Paliouras MPLoS ONE 2014-11-19;9(11):e113190.

MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RBNat Commun 2014-11-18;5:5413.

Targeted protein degradation as a tumor suppressor.Arat NO, Harrington LCell Cycle 2014-11-15;13(22):3473.

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