Publications
IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.
Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.Proc. Natl. Acad. Sci. U.S.A. 2013-12-24;110(52):E5088-97.
The Coming of Age of Phosphoproteomics--from Large Data Sets to Inference of Protein Functions.Mol. Cell Proteomics 2013-12-01;12(12):3453-64.
Early detection of liver steatosis by magnetic resonance imaging in rats infused with glucose and Intralipid solutions and correlation to insulin levels.Metab. Clin. Exp. 2013-12-01;62(12):1850-7.
Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.Cytoskeleton (Hoboken) 2013-11-01;70(11):741-54.
A host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle production.J. Virol. 2013-11-01;87(21):11704-20.
Regulation of Stress-Inducible Phosphoprotein 1 Nuclear Retention by Protein Inhibitor of Activated STAT PIAS1.Mol. Cell Proteomics 2013-11-01;12(11):3253-70.
Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly.J. Med. Genet. 2013-11-01;50(11):740-4.
Funding considerations for the disclosure of genetic incidental findings in biobank research.Clin. Genet. 2013-11-01;84(5):397-406.
Insulin Activates RSK (p90 Ribosomal S6 Kinase) to Trigger a New Negative Feedback Loop That Regulates Insulin Signaling for Glucose Metabolism.J. Biol. Chem. 2013-10-25;288(43):31165-76.
Rapamycin Resistance: mTORC1 Substrates Hold Some of the Answers.Curr. Biol. 2013-10-07;23(19):R880-3.
The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia.Leukemia 2013-10-01;27(10):2047-55.
RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance.Oncogene 2013-09-19;32(38):4480-9.
HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA.Nat Commun 2013-09-04;4:2388.
Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma.Cancer Discov 2013-09-01;3(9):1002-1019.
Harnessing virtual machines to simplify next-generation DNA sequencing analysis.Bioinformatics 2013-09-01;29(17):2075-83.
Targeted Identification of SUMOylation Sites in Human Proteins Using Affinity Enrichment and Paralog-specific Reporter Ions.Mol. Cell Proteomics 2013-09-01;12(9):2536-50.
Quantitative proteomics reveals the induction of mitophagy in tumor necrosis factor-α-activated (TNFα) macrophages.Mol. Cell Proteomics 2013-09-01;12(9):2394-407.
Nystatin nanosizing enhances in vitro and in vivo antifungal activity against Candida albicans.J. Antimicrob. Chemother. 2013-09-01;68(9):2099-105.
Engineering the Pattern of Protein Glycosylation Modulates the Thermostability of a GH11 Xylanase.J. Biol. Chem. 2013-08-30;288(35):25522-34.
RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.Blood 2013-08-29;122(9):1545-55.
Genetic interaction between Kit and Scl.Blood 2013-08-15;122(7):1150-61.
RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells.Proc. Natl. Acad. Sci. U.S.A. 2013-08-13;110(33):13522-7.
The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex.J. Cell Biol. 2013-07-22;202(2):251-60.
Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression.J. Cell Biol. 2013-07-22;202(2):277-93.
Leishmania Evades Host Immunity by Inhibiting Antigen Cross-Presentation through Direct Cleavage of the SNARE VAMP8.Cell Host Microbe 2013-07-17;14(1):15-25.
Cell coordination of collective migration by Rab11 and Moesin.Commun Integr Biol 2013-07-01;6(4):e24587.
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.Nat. Chem. Biol. 2013-07-01;9(7):428-36.
Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia.Stem Cells 2013-07-01;31(7):1434-45.
Aiding and abetting cancer: mRNA export and the nuclear pore.Trends Cell Biol. 2013-07-01;23(7):328-35.
Positive regulation of insulin signaling by neuraminidase 1.Diabetes 2013-07-01;62(7):2338-46.
NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.Blood 2013-06-27;121(26):5203-7.
RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.Oncogene 2013-06-13;32(24):2917-26.
Displacement of N/Q-rich Peptides on TiO2 Beads Enhances the Depth and Coverage of Yeast Phosphoproteome Analyses.J. Proteome Res. 2013-06-07;12(6):2905-13.
Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses.PLoS Pathog. 2013-06-01;9(6):e1003416.
Transcriptome sequencing of neonatal thymic epithelial cells.Sci Rep 2013-05-17;3:1860.
GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.J. Cell. Sci. 2013-05-15;126(Pt 10):2285-93.
Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.Biochem. Biophys. Res. Commun. 2013-05-10;434(3):614-9.
Octameric CENP-A Nucleosomes Are Present at Human Centromeres throughout the Cell Cycle.Curr. Biol. 2013-05-06;23(9):764-9.
Unraveling the structural basis of GPCR activation and inactivation.Nat. Struct. Mol. Biol. 2013-05-01;20(5):539-41.
The Oncogene eIF4E: Using Biochemical Insights to Target Cancer.J. Interferon Cytokine Res. 2013-05-01;33(5):227-38.
Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity.Exp. Hematol. 2013-05-01;41(5):470-478.e4.
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.Genes Dev. 2013-04-15;27(8):900-15.
eIF4E3, a new actor in mRNA metabolism and tumor suppression.Cell Cycle 2013-04-15;12(8):1159-60.
Proteomics: From protein structures to clinical applications.J Proteomics 2013-04-09;81:1-2.
Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics.J Proteomics 2013-04-09;81:80-90.
Modelling acute leukemias in mice: clonal evolution and the emergence of leukemic stem cells.BMC Proc 2013-04-04;7(Suppl 2 Sao Paulo Advanced School of Comparative Oncology: AbstractsClaudia Aparecida Rainho, Patricia Pintor dos Reis and Silvia Regina RogattoPublication of this supplement was funded by the Sao Paulo Research Foundation (FAPESP)):K1.
Short Telomeres in ESCs Lead to Unstable Differentiation.Cell Stem Cell 2013-04-04;12(4):479-86.
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.Chromosome Res. 2013-04-01;21(2):101-6.
A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells.Proteomics 2013-04-01;13(7):1108-20.
The expanding roles of Gβγ subunits in G protein-coupled receptor signaling and drug action.Pharmacol. Rev. 2013-04-01;65(2):545-77.
Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility.Mol. Cell. Biol. 2013-04-01;33(8):1657-70.
Altered immune response differentially enhances susceptibility to Cryptococcus neoformans and Cryptococcus gattii infection in mice expressing the HIV-1 transgene.Infect. Immun. 2013-04-01;81(4):1100-13.
Safety and cost-effectiveness of outpatient autologous stem cell transplantation in patients with multiple myeloma.Biol. Blood Marrow Transplant. 2013-04-01;19(4):547-51.
A yeast chemical genetic screen identifies inhibitors of human telomerase.Chem. Biol. 2013-03-21;20(3):333-40.
Cancer: Trouble upstream.Nature 2013-03-21;495(7441):320-1.
Michel j. Bertrand (1945-2012).Rapid Commun. Mass Spectrom. 2013-03-15;27(5):654.
eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition.Proc. Natl. Acad. Sci. U.S.A. 2013-03-05;110(10):3877-82.
Rab11 regulates cell-cell communication during collective cell movements.Nat. Cell Biol. 2013-03-01;15(3):317-24.
Insights into the insect salivary gland proteome: diet-associated changes in caterpillar labial salivary proteins.J. Insect Physiol. 2013-03-01;59(3):351-66.
Nucleosomal composition at the centromere: a numbers game.Chromosome Res. 2013-03-01;21(1):27-36.
The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.Genes Immun. 2013-03-01;14(2):115-26.
Dividing in Epithelia: Cells Let Loose during Cytokinesis.Dev. Cell 2013-02-25;24(4):336-8.
Proteomics analysis of Herpes Simplex Virus type 1-infected cells reveals dynamic changes of viral protein expression, ubiquitylation and phosphorylation.J. Proteome Res. 2013-02-18;12(4):1820-29.
Bioinactive ACTH causing glucocorticoid deficiency.J. Clin. Endocrinol. Metab. 2013-02-01;98(2):736-42.
A strategy for modulation of enzymes in the ubiquitin system.Science 2013-02-01;339(6119):590-5.
Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors.Mol. Pharmacol. 2013-02-01;83(2):416-28.
In search of immunodominant minor histocompatibility antigens.Biol. Blood Marrow Transplant. 2013-02-01;19(2):171-2.
Autism-related deficits via dysregulated eIF4E-dependent translational control.Nature 2013-01-17;493(7432):371-7.
Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.Blood 2013-01-03;121(1):107-17.
A rare case of large skull base meningioma mimicking otitis media with effusion.Case Rep Med 2013-01-01;2013:396805.
Comparative xylose metabolism among the Ascomycetes C. albicans, S. stipitis and S. cerevisiae.PLoS ONE 2013-01-01;8(11):e80733.
RNA-Seq Reveals Spliceosome and Proteasome Genes as Most Consistent Transcripts in Human Cancer Cells.PLoS ONE 2013-01-01;8(9):e72884.
Technology combination to address GPCR allosteric modulator drug-discovery pitfalls.Drug Discov Today Technol 2013-01-01;10(2):e261-7.
Interleukin-21 accelerates thymic recovery from glucocorticoïd-induced atrophy.PLoS ONE 2013-01-01;8(9):e72801.
Telomeres, a busy platform for cell signaling.Front Oncol 2013-01-01;3:146.
Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions.Mol. Syst. Biol. 2013-01-01;9:669.
The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: version 2.0 update.Database (Oxford) 2013-01-01;2013(0):bat026.
Expression and functions of galectin-7 in human and murine melanomas.PLoS ONE 2013-01-01;8(5):e63307.
Systematic curation of protein and genetic interaction data for computable biology.BMC Biol. 2013-01-01;11:43.
Correction of spatial bias in oligonucleotide array data.Adv Bioinformatics 2013-01-01;2013:167915.
Mechanisms and insights into drug resistance in cancer.Front Pharmacol 2013-01-01;4:28.
The BioGRID interaction database: 2013 update.Nucleic Acids Res. 2013-01-01;41(Database issue):D816-23.
Drosophila s2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes.Traffic 2013-01-01;14(1):82-96.
Improved antifungal activity of itraconazole-loaded PEG/PLA nanoparticles.J Microencapsul 2013-01-01;30(3):205-17.
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