Publications
IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.
Cancer: A drug-resistant duo.Nature 2011-12-15;480(7377):329-30.
DNA-binding properties of Smc6, a core component of the Smc5-6 DNA repair complex.Biochem. Biophys. Res. Commun. 2011-12-09;416(1-2):80-5.
A prospective pilot study investigating the musculoskeletal pain in postmenopausal breast cancer patients receiving aromatase inhibitor therapy.Curr Oncol 2011-12-01;18(6):285-94.
PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.DNA Repair (Amst.) 2011-11-10;10(11):1164-73.
Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors.Blood 2011-11-10;118(19):5163-73.
Structural messenger RNA contains cytokeratin polymerization and depolymerization signals.Cell Tissue Res. 2011-11-01;346(2):209-22.
HCaRG accelerates tubular repair after ischemic kidney injury.J. Am. Soc. Nephrol. 2011-11-01;22(11):2077-89.
Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production.J. Virol. 2011-11-01;85(21):11022-37.
Incidence and prognostic value of eosinophilia in chronic graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation.Biol. Blood Marrow Transplant. 2011-11-01;17(11):1673-8.
C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.Blood 2011-10-27;118(17):4682-9.
Cytokinesis: cells go back and forth about division.Curr. Biol. 2011-10-25;21(20):R848-50.
Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.Proc. Natl. Acad. Sci. U.S.A. 2011-10-25;108(43):E914-23.
Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis.Proc. Natl. Acad. Sci. U.S.A. 2011-10-18;108(42):17343-8.
Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis.J. Cell Biol. 2011-10-03;195(1):99-112.
Genome-wide Fitness Profiles Reveal a Requirement for Autophagy During Yeast Fermentation.G3 (Bethesda) 2011-10-01;1(5):353-67.
A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells.Sci Signal 2011-09-20;4(191):ra60.
Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes.J. Immunol. 2011-09-15;187(6):3133-44.
Next-generation leukemia immunotherapy.Blood 2011-09-15;118(11):2951-9.
NMR structure of a 4 x 4 nucleotide RNA internal loop from an R2 retrotransposon: identification of a three purine-purine sheared pair motif and comparison to MC-SYM predictions.RNA 2011-09-01;17(9):1664-77.
Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.EMBO J. 2011-08-03;30(15):3052-64.
Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors.Expert Opin Drug Discov 2011-08-01;6(8):811-25.
PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos.PLoS Genet. 2011-08-01;7(8):e1002227.
Microcalcifications around a collagen-based breast biopsy marker: complication of biopsy with a percutaneous marking system.AJR Am J Roentgenol 2011-08-01;197(2):W353-7.
Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2).J. Biol. Chem. 2011-07-15;286(28):24638-48.
PSICQUIC and PSISCORE: accessing and scoring molecular interactions.Nat. Methods 2011-07-01;8(7):528-9.
ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses.Proteomics 2011-07-01;11(13):2654-71.
Roles for MSI2 and PROX1 in hematopoietic stem cell activity.Curr. Opin. Hematol. 2011-07-01;18(4):203-7.
Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens.Leukemia 2011-07-01;25(7):1197-200.
CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.Int. J. Cancer 2011-07-01;129(1):225-32.
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.Cell 2011-06-24;145(7):1075-87.
The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis.Curr. Biol. 2011-06-21;21(12):1074-9.
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.Nat. Chem. Biol. 2011-06-01;7(6):348-50.
Cell size: chromosomes get slapped by a midzone ruler.Curr. Biol. 2011-05-24;21(10):R388-90.
G protein-coupled receptor modulation with pepducins: moving closer to the clinic.Ann. N. Y. Acad. Sci. 2011-05-01;1226:34-49.
Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer.Clin. Cancer Res. 2011-05-01;17(9):2874-84.
Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Antimicrob. Agents Chemother. 2011-05-01;55(5):2212-23.
Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation.Biomaterials 2011-05-01;32(13):3481-6.
The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.J. Cell Biol. 2011-04-04;193(1):155-69.
An anticlastogenic function for the Polycomb Group gene Bmi1.Proc. Natl. Acad. Sci. U.S.A. 2011-03-29;108(13):5284-9.
Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.J. Biol. Chem. 2011-03-18;286(11):9360-72.
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation.PLoS Genet. 2011-03-01;7(3):e1001354.
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.Microbiol. Mol. Biol. Rev. 2011-03-01;75(1):50-83.
Evolution of the repertoire of nuclear receptor binding sites in genomes.Mol. Cell. Endocrinol. 2011-03-01;334(1-2):76-82.
Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.J. Biol. Chem. 2011-02-25;286(8):6470-8.
PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.Curr. Biol. 2011-02-22;21(4):259-69.
Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex.Cell Cycle 2011-02-15;10(4):690-700.
Fitness without exhaustion.Blood 2011-02-10;117(6):1776.
Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation.Structure 2011-02-09;19(2):221-31.
SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.Blood 2011-02-03;117(5):1734-44.
A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.Mol. Cell Proteomics 2011-02-01;10(2):M110.004796.
Mechanistic principles of RAF kinase signaling.Cell. Mol. Life Sci. 2011-02-01;68(4):553-65.
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.Circ. Res. 2011-01-21;108(2):176-83.
RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.Blood 2011-01-13;117(2):e27-38.
ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).J. Biol. Chem. 2011-01-07;286(1):567-77.
PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.Nat Commun 2011-01-01;2:598.
Targeting the oncogene eIF4E in cancer: From the bench to clinical trials.Clin Invest Med 2011-01-01;34(6):E315.
Affinity purification of protein complexes in C. elegans.Methods Cell Biol. 2011-01-01;106:289-322.
The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.Mol. Syst. Biol. 2011-01-01;7:533.
Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast.Genome Biol. 2011-01-01;12(8):R82.
Phosphorylation network rewiring by gene duplication.Mol. Syst. Biol. 2011-01-01;7:504.
Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.PLoS ONE 2011-01-01;6(4):e19279.
The exon junction complex: a splicing factor for long intron containing transcripts?Fly (Austin) 2011-01-01;5(3):224-33.
Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.PLoS ONE 2011-01-01;6(2):e14714.
Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells.J. Mol. Recognit. 2011-01-01;24(2):188-98.
Paving the way for targeting RSK in cancer.Expert Opin. Ther. Targets 2011-01-01;15(1):5-9.
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