IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration.Assaker G, Ramel D, Wculek SK, González-Gaitán M, Emery GProc. Natl. Acad. Sci. U.S.A. 2010-12-28;107(52):22558-63.

Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes.Montembault E, Zhang W, Przewloka MR, Archambault V, Sevin EW, Laue ED, Glover DM, D'Avino PPJ. Cell Biol. 2010-12-27;191(7):1351-65.

A comprehensive map of the mTOR signaling network.Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano HMol. Syst. Biol. 2010-12-21;6:453.

When enough is enough: detrimental effects of excess histones.Villeneuve V, Verreault ACell Cycle 2010-12-15;9(24):4783.

Multiplexing of multicolor bioluminescence resonance energy transfer.Breton B, Sauvageau É, Zhou J, Bonin H, Le Gouill C, Bouvier MBiophys. J. 2010-12-15;99(12):4037-46.

Photodepletion differentially affects CD4+ Tregs versus CD4+ effector T cells from patients with chronic graft-versus-host disease.Bastien JP, Krosl G, Therien C, Rashkovan M, Scotto C, Cohen S, Allan DS, Hogge D, Egeler RM, Perreault C, Roy DCBlood 2010-12-02;116(23):4859-69.

[The greater RTK/RAS/ERK signalling pathway: how genetics has helped piece together a signalling network].Ashton-Beaucage D, Therrien MMed Sci (Paris) 2010-12-01;26(12):1067-73.

[mTOR, the mammalian target of rapamycin].Julien LA, Roux PPMed Sci (Paris) 2010-12-01;26(12):1056-60.

A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A.Lagana A, Dorn JF, De Rop V, Ladouceur AM, Maddox AS, Maddox PSNat. Cell Biol. 2010-12-01;12(12):1186-93.

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto EEMBO J. 2010-12-01;29(23):3939-51.

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