IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration.Assaker G, Ramel D, Wculek SK, González-Gaitán M, Emery GProc. Natl. Acad. Sci. U.S.A. 2010-12-28;107(52):22558-63.

Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes.Montembault E, Zhang W, Przewloka MR, Archambault V, Sevin EW, Laue ED, Glover DM, D'Avino PPJ. Cell Biol. 2010-12-27;191(7):1351-65.

A comprehensive map of the mTOR signaling network.Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano HMol. Syst. Biol. 2010-12-21;6:453.

When enough is enough: detrimental effects of excess histones.Villeneuve V, Verreault ACell Cycle 2010-12-15;9(24):4783.

Multiplexing of multicolor bioluminescence resonance energy transfer.Breton B, Sauvageau É, Zhou J, Bonin H, Le Gouill C, Bouvier MBiophys. J. 2010-12-15;99(12):4037-46.

Photodepletion differentially affects CD4+ Tregs versus CD4+ effector T cells from patients with chronic graft-versus-host disease.Bastien JP, Krosl G, Therien C, Rashkovan M, Scotto C, Cohen S, Allan DS, Hogge D, Egeler RM, Perreault C, Roy DCBlood 2010-12-02;116(23):4859-69.

[The greater RTK/RAS/ERK signalling pathway: how genetics has helped piece together a signalling network].Ashton-Beaucage D, Therrien MMed Sci (Paris) 2010-12-01;26(12):1067-73.

[mTOR, the mammalian target of rapamycin].Julien LA, Roux PPMed Sci (Paris) 2010-12-01;26(12):1056-60.

A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A.Lagana A, Dorn JF, De Rop V, Ladouceur AM, Maddox AS, Maddox PSNat. Cell Biol. 2010-12-01;12(12):1186-93.

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto EEMBO J. 2010-12-01;29(23):3939-51.

Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.Rousseau J, Klinger S, Rachalski A, Turgeon B, Déléris P, Vigneault E, Poirier-Héon JF, Davoli MA, Mechawar N, El Mestikawy S, Cermakian N, Meloche SMol. Cell. Biol. 2010-12-01;30(24):5752-63.

RNA G-Quadruplexes in the model plant species Arabidopsis thaliana: prevalence and possible functional roles.Mullen MA, Olson KJ, Dallaire P, Major F, Assmann SM, Bevilacqua PCNucleic Acids Res. 2010-12-01;38(22):8149-63.

Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity.René P, Le Gouill C, Pogozheva ID, Lee G, Mosberg HI, Farooqi IS, Valenzano KJ, Bouvier MJ. Pharmacol. Exp. Ther. 2010-12-01;335(3):520-32.

The myriad roles of Anillin during cytokinesis.Piekny AJ, Maddox ASSemin. Cell Dev. Biol. 2010-12-01;21(9):881-91.

Combining resonance energy transfer methods reveals a complex between the alpha2A-adrenergic receptor, Galphai1beta1gamma2, and GRK2.Breton B, Lagacé M, Bouvier MFASEB J. 2010-12-01;24(12):4733-43.

Comprehensive BRCA1 and BRCA2 mutation analyses and review of French Canadian families with at least three cases of breast cancer.Cavallone L, Arcand SL, Maugard CM, Nolet S, Gaboury LA, Mes-Masson AM, Ghadirian P, Provencher D, Tonin PNFam. Cancer 2010-12-01;9(4):507-17.

Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication.Day TA, Palle K, Barkley LR, Kakusho N, Zou Y, Tateishi S, Verreault A, Masai H, Vaziri CJ. Cell Biol. 2010-11-29;191(5):953-66.

Cell biology. Puzzled by PML.Culjkovic-Kraljacic B, Borden KLScience 2010-11-26;330(6008):1183-4.

Actomyosin tube formation in polar body cytokinesis requires Anillin in C. elegans.Dorn JF, Zhang L, Paradis V, Edoh-Bedi D, Jusu S, Maddox PS, Maddox ASCurr. Biol. 2010-11-23;20(22):2046-51.

An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling.Patel M, Margaron Y, Fradet N, Yang Q, Wilkes B, Bouvier M, Hofmann K, Côté JFCurr. Biol. 2010-11-23;20(22):2021-7.

Chromatin regulatory mechanisms in pluripotency.Lessard JA, Crabtree GRAnnu. Rev. Cell Dev. Biol. 2010-11-10;26:503-32.

Caterpillar- and salivary-specific modification of plant proteins.Thivierge K, Prado A, Driscoll BT, Bonneil E, Thibault P, Bede JCJ. Proteome Res. 2010-11-05;9(11):5887-95.

The T-ALL paradox in cancer.Hoang T, Hoang TNat. Med. 2010-11-01;16(11):1185-6.

HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells.Lebert-Ghali CE, Fournier M, Dickson GJ, Thompson A, Sauvageau G, Bijl JJExp. Hematol. 2010-11-01;38(11):1074-1086.e1-5.

Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.Oner SS, An N, Vural A, Breton B, Bouvier M, Blumer JB, Lanier SMJ. Biol. Chem. 2010-10-29;285(44):33949-58.

Molecular characterization of the evolution of phagosomes.Boulais J, Trost M, Landry CR, Dieckmann R, Levy ED, Soldati T, Michnick SW, Thibault P, Desjardins MMol. Syst. Biol. 2010-10-19;6:423.

The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.Ashton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefrançois M, Chagnon P, Gendron P, Caron-Lizotte O, Bonneil E, Thibault P, Therrien MCell 2010-10-15;143(2):251-62.

Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC.Durand S, Feldhammer M, Bonneil E, Thibault P, Pshezhetsky AVJ. Biol. Chem. 2010-10-08;285(41):31233-42.

A two-locus system controls susceptibility to colitis-associated colon cancer in mice.Van Der Kraak L, Meunier C, Turbide C, Jothy S, Gaboury L, Marcus V, Chang SY, Beauchemin N, Gros POncotarget 2010-10-01;1(6):436-46.

[Hepatitis C virus subverts pattern recognition receptors-mediated control of adaptative immunity orchestrated by dendritic cells].Rodrigue-Gervais IG, Lamarre DMed Sci (Paris) 2010-10-01;26(10):869-74.

Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?Borden KL, Culjkovic-Kraljacic BLeuk. Lymphoma 2010-10-01;51(10):1805-15.

Medicine. The blood stem cell Holy Grail?Sauvageau G, Humphries RKScience 2010-09-10;329(5997):1291-2.

A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations.Krosl J, Mamo A, Chagraoui J, Wilhelm BT, Girard S, Louis I, Lessard J, Perreault C, Sauvageau GBlood 2010-09-09;116(10):1678-84.

Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.Sauvageau M, Sauvageau GCell Stem Cell 2010-09-03;7(3):299-313.

Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I Verteuil D, Muratore-Schroeder TL, Granados DP, Fortier MH, Hardy MP, Bramoullé A, Caron E, Vincent K, Mader S, Lemieux S, Thibault P, Perreault CMol. Cell Proteomics 2010-09-01;9(9):2034-47.

Three-step model for condensin activation during mitotic chromosome condensation.Bazile F, St-Pierre J, D'Amours DCell Cycle 2010-08-15;9(16):3243-55.

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway.Goupil E, Tassy D, Bourguet C, Quiniou C, Wisehart V, Pétrin D, Le Gouill C, Devost D, Zingg HH, Bouvier M, Saragovi HU, Chemtob S, Lubell WD, Claing A, Hébert TE, Laporte SAJ. Biol. Chem. 2010-08-13;285(33):25624-36.

RNA structure determination using SAXS data.Yang S, Parisien M, Major F, Roux BJ Phys Chem B 2010-08-12;114(31):10039-48.

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg NProc. Natl. Acad. Sci. U.S.A. 2010-08-10;107(32):14134-9.

Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel.Chatel-Chaix L, Baril M, Lamarre DViruses 2010-08-01;2(8):1752-65.

T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling.Giroux M, Delisle JS, O'Brien A, Hébert MJ, Perreault CJ. Immunol. 2010-08-01;185(3):1568-76.

Sensory neuron-specific MAS-related gene-X1 receptors resist agonist-promoted endocytosis.Solinski HJ, Boekhoff I, Bouvier M, Gudermann T, Breit AMol. Pharmacol. 2010-08-01;78(2):249-59.

Protein-protein interactions monitored in cells from transgenic mice using bioluminescence resonance energy transfer.Audet M, Lagacé M, Silversides DW, Bouvier MFASEB J. 2010-08-01;24(8):2829-38.

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola MBioinformatics 2010-07-15;26(14):1804-5.

An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau GCell Stem Cell 2010-07-02;7(1):101-13.

Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai.Oner SS, Maher EM, Breton B, Bouvier M, Blumer JBJ. Biol. Chem. 2010-07-02;285(27):20588-94.

Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy.Wurtele H, Tsao S, Lépine G, Mullick A, Tremblay J, Drogaris P, Lee EH, Thibault P, Verreault A, Raymond MNat. Med. 2010-07-01;16(7):774-80.

Designing small multiple-target artificial RNAs.De Guire V, Caron M, Scott N, Ménard C, Gaumont-Leclerc MF, Chartrand P, Major F, Ferbeyre GNucleic Acids Res. 2010-07-01;38(13):e140.

Clinical and biochemical features of seven adult adrenal ganglioneuromas.Rondeau G, Nolet S, Latour M, Braschi S, Gaboury L, Lacroix A, Panzini B, Arjane P, Cohade C, Bourdeau IJ. Clin. Endocrinol. Metab. 2010-07-01;95(7):3118-25.

Differential roles of PtdIns(4,5)P2 and phosphorylation in moesin activation during Drosophila development.Roch F, Polesello C, Roubinet C, Martin M, Roy C, Valenti P, Carreno S, Mangeat P, Payre FJ. Cell. Sci. 2010-06-15;123(Pt 12):2058-67.

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Tremblay M, Tremblay CS, Herblot S, Aplan PD, Hébert J, Perreault C, Hoang TGenes Dev. 2010-06-01;24(11):1093-105.

Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells.Demers M, Rose AA, Grosset AA, Biron-Pain K, Gaboury L, Siegel PM, St-Pierre YAm. J. Pathol. 2010-06-01;176(6):3023-31.

Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation.Voisin L, Saba-El-Leil MK, Julien C, Frémin C, Meloche SMol. Cell. Biol. 2010-06-01;30(12):2918-32.

C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.Tanguay PL, Rodier G, Meloche SBiochem. J. 2010-05-15;428(1):103-11.

Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.Tcherkezian J, Brittis PA, Thomas F, Roux PP, Flanagan JGCell 2010-05-14;141(4):632-44.

[It takes two RAFs to tango].Lavoie H, Therrien MMed Sci (Paris) 2010-05-01;26(5):459-60.

Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments.Rochdi MD, Vargas GA, Carpentier E, Oligny-Longpré G, Chen S, Kovoor A, Gitelman SE, Rosenthal SM, von Zastrow M, Bouvier MMol. Pharmacol. 2010-05-01;77(5):836-45.

Understanding the role of asymmetric cell division in cancer using C. elegans.Hyenne V, Chartier NT, Labbé JCDev. Dyn. 2010-05-01;239(5):1378-87.

Late acute renal failure due to bilateral kidney infiltration by ALL as single manifestation of relapse after allogeneic transplantation.Detrait M, Meunier C, Roy DC, Kiss T, Lachance S, Cohen S, Busque L, Sauvageau G, Roy JBone Marrow Transplant. 2010-05-01;45(5):953-4.

High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma.Sartelet H, Ohta S, Barrette S, Rougemont AL, Brevet M, Regairaz M, Harvey I, Bernard C, Fabre M, Gaboury L, Oligny LL, Bosq J, Valteau-Couanet D, Vassal GHistopathology 2010-04-01;56(5):607-16.

Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer.Rose AA, Grosset AA, Dong Z, Russo C, Macdonald PA, Bertos NR, St-Pierre Y, Simantov R, Hallett M, Park M, Gaboury L, Siegel PMClin. Cancer Res. 2010-04-01;16(7):2147-56.

Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.Volpon L, Osborne MJ, Capul AA, de la Torre JC, Borden KLProc. Natl. Acad. Sci. U.S.A. 2010-03-23;107(12):5441-6.

An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein.García CC, Topisirovic I, Djavani M, Borden KL, Damonte EB, Salvato MSBiochem. Biophys. Res. Commun. 2010-03-19;393(4):625-30.

Dendritic cell inhibition is connected to exhaustion of CD8+ T cell polyfunctionality during chronic hepatitis C virus infection.Rodrigue-Gervais IG, Rigsby H, Jouan L, Sauvé D, Sékaly RP, Willems B, Lamarre DJ. Immunol. 2010-03-15;184(6):3134-44.

Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JLJ. Biol. Chem. 2010-03-05;285(10):7805-17.

Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia.Hoang TSci Transl Med 2010-03-03;2(21):21ps10.

[Mechanisms of asymmetric cell division: from model organisms to tumorigenesis]Chartier NT, Hyenne V, Labbé JCMed Sci (Paris) 2010-03-01;26(3):251-7.

Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche SCell Cycle 2010-03-01;9(5):975-9.

Forward genetics in Candida albicans that reveals the Arp2/3 complex is required for hyphal formation, but not endocytosis.Epp E, Walther A, Lépine G, Leon Z, Mullick A, Raymond M, Wendland J, Whiteway MMol. Microbiol. 2010-03-01;75(5):1182-98.

Multimerization of Staufen1 in live cells.Martel C, Dugré-Brisson S, Boulay K, Breton B, Lapointe G, Armando S, Trépanier V, Duchaîne T, Bouvier M, Desgroseillers LRNA 2010-03-01;16(3):585-97.

Anillin.Zhang L, Maddox ASCurr. Biol. 2010-02-23;20(4):R135-6.

Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability.Zakaria C, Kassahun H, Yang X, Labbé JC, Nilsen H, Ramotar DDNA Repair (Amst.) 2010-02-04;9(2):169-76.

Differential requirements for STRAD in LKB1-dependent functions in C. elegans.Narbonne P, Hyenne V, Li S, Labbé JC, Roy RDevelopment 2010-02-01;137(4):661-70.

Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease.Jouan L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Boucher G, Bilodeau M, Grandvaux N, Lamarre DJ. Hepatol. 2010-02-01;52(2):167-75.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.Julien LA, Carriere A, Moreau J, Roux PPMol. Cell. Biol. 2010-02-01;30(4):908-21.

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells.Lacombe J, Herblot S, Rojas-Sutterlin S, Haman A, Barakat S, Iscove NN, Sauvageau G, Hoang TBlood 2010-01-28;115(4):792-803.

Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease.Wang TT, Dabbas B, Laperriere D, Bitton AJ, Soualhine H, Tavera-Mendoza LE, Dionne S, Servant MJ, Bitton A, Seidman EG, Mader S, Behr MA, White JHJ. Biol. Chem. 2010-01-22;285(4):2227-31.

Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.Fortier S, Bilodeau M, Macrae T, Laverdure JP, Azcoitia V, Girard S, Chagraoui J, Ringuette N, Hébert J, Krosl J, Mayotte N, Sauvageau GPLoS Genet. 2010-01-01;6(12):e1001241.

Subcellular phosphoproteomics.Trost M, Bridon G, Desjardins M, Thibault PMass Spectrom Rev 2010-01-01;29(6):962-90.

LRCH proteins: a novel family of cytoskeletal regulators.Foussard H, Ferrer P, Valenti P, Polesello C, Carreno S, Payre FPLoS ONE 2010-01-01;5(8):e12257.

Early T cell differentiation lessons from T-cell acute lymphoblastic leukemia.Tremblay CS, Hoang T, Hoang TProg Mol Biol Transl Sci 2010-01-01;92:121-56.

The origin and role of MHC class I-associated self-peptides.Perreault CProg Mol Biol Transl Sci 2010-01-01;92:41-60.

Questions arising from "genome duplication and T cell immunity".Perreault CProg Mol Biol Transl Sci 2010-01-01;92:37; discussion 38-9.

RKB: a Semantic Web knowledge base for RNA.Cruz-Toledo J, Dumontier M, Parisien M, Major FJ Biomed Semantics 2010-01-01;1 Suppl 1:S2.

Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression.Soucy-Faulkner A, Mukawera E, Fink K, Martel A, Jouan L, Nzengue Y, Lamarre D, Vande Velde C, Grandvaux NPLoS Pathog. 2010-01-01;6(6):e1000930.

Free centrosomes: where do they all come from?Archambault V, Pinson XFly (Austin) 2010-01-01;4(2):172-7.

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.Frémin C, Meloche SJ Hematol Oncol 2010-01-01;3:8.

[Hopes and challenges in biomedical research].Bouvier M, Chneiweiss HMed Sci (Paris) 2010-01-01;26(1):3-4.

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DCJ. Biol. Chem. 2010-01-01;285(1):80-94.

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