Publications
IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.
Killer granzyme B linked to N-myc- and c-myc-dependent HSC survival: isn't that comyc?Cell Stem Cell 2008-12-04;3(6):579-80.
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.J. Cell. Physiol. 2008-12-01;217(3):778-88.
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.Proc. Natl. Acad. Sci. U.S.A. 2008-11-11;105(45):17414-9.
Roux-en-Y diversion for intractable reflux after esophagectomy.Ann. Thorac. Surg. 2008-11-01;86(5):1646-52.
Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis.J. Pathol. 2008-11-01;216(3):317-27.
Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?Biochim. Biophys. Acta 2008-11-01;1783(11):2145-54.
Ribavirin targets eIF4E dependent Akt survival signaling.Biochem. Biophys. Res. Commun. 2008-10-24;375(3):341-5.
Evidence for Hox and E2A-PBX1 collaboration in mouse T-cell leukemia.Oncogene 2008-10-23;27(49):6356-64.
C. elegans Brat homologs regulate PAR protein-dependent polarity and asymmetric cell division.Dev. Biol. 2008-09-15;321(2):368-78.
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.Curr. Biol. 2008-09-09;18(17):1269-77.
Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction.J. Biol. Chem. 2008-09-05;283(36):24659-72.
The IKK-related kinases: from innate immunity to oncogenesis.Cell Res. 2008-09-01;18(9):889-99.
Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.Nat. Struct. Mol. Biol. 2008-09-01;15(9):998.
A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.Genes Dev. 2008-09-01;22(17):2385-99.
Comprehensive profiling of histone modifications using a label-free approach and its applications in determining structure-function relationships.Anal. Chem. 2008-09-01;80(17):6698-707.
Graft-versus-host disease causes failure of donor hematopoiesis and lymphopoiesis in interferon-gamma receptor-deficient hosts.Blood 2008-09-01;112(5):2111-9.
Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle.J. Cell Biol. 2008-08-25;182(4):631-9.
PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.Genes Dev. 2008-08-01;22(15):2085-92.
Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.Genetics 2008-08-01;179(4):1769-84.
Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly.Cell 2008-07-25;134(2):244-55.
The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling.Immunity 2008-07-18;29(1):57-67.
Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46.Structure 2008-07-01;16(7):1077-85.
Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.Nat. Struct. Mol. Biol. 2008-07-01;15(7):738-45.
Insights into signaling from the beta2-adrenergic receptor structure.Nat. Chem. Biol. 2008-07-01;4(7):397-403.
Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.Mol. Pharmacol. 2008-07-01;74(1):162-72.
Clothing up DNA for all seasons: Histone chaperones and nucleosome assembly pathways.FEBS Lett. 2008-06-18;582(14):1938-49.
NMR assignment of the arenaviral protein Z from Lassa fever virus.Biomol NMR Assign 2008-06-01;2(1):81-4.
Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins.J. Biol. Chem. 2008-05-30;283(22):15078-88.
Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance.Eukaryotic Cell 2008-05-01;7(5):836-47.
Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes.Eur. J. Immunol. 2008-05-01;38(5):1225-30.
Polycomb group genes: keeping stem cell activity in balance.PLoS Biol. 2008-04-29;6(4):e113.
The eIF4E RNA regulon promotes the Akt signaling pathway.J. Cell Biol. 2008-04-07;181(1):51-63.
Fast-tracking steroid receptor crystallization.Nat. Chem. Biol. 2008-04-01;4(4):226-7.
The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila.Dev. Cell 2008-04-01;14(4):535-46.
Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme.RNA 2008-04-01;14(4):736-48.
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association.J. Virol. 2008-04-01;82(8):3984-96.
Modulation of the phagosome proteome by interferon-gamma.Mol. Cell Proteomics 2008-04-01;7(4):697-715.
Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses: application to cell signaling events of interferon-gamma-stimulated macrophages.Mol. Cell Proteomics 2008-04-01;7(4):645-60.
The MHC class I peptide repertoire is molded by the transcriptome.J. Exp. Med. 2008-03-17;205(3):595-610.
The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data.Nature 2008-03-06;452(7183):51-5.
Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization.Traffic 2008-03-01;9(3):305-24.
The effect of covalent cross-links between the membrane components of microcapsules on the dissemination of encapsulated malignant cells.Biomaterials 2008-03-01;29(7):917-24.
Newly-isolated HPV97, related to HPV18 and 45 is frequently detected in HIV-positive men from the Montreal area.Int. J. Cancer 2008-03-01;122(5):1195-7.
Chromosome segregation: centromeres get bent.Curr. Biol. 2008-02-26;18(4):R159-61.
CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.Proc. Natl. Acad. Sci. U.S.A. 2008-02-26;105(8):2836-41.
SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.J. Cell Biol. 2008-02-25;180(4):771-85.
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.EMBO J. 2008-02-20;27(4):679-91.
Why T cells of thymic versus extrathymic origin are functionally different.J. Immunol. 2008-02-15;180(4):2299-312.
Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer.Biophys. J. 2008-02-01;94(3):1001-9.
Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia.Blood 2008-01-15;111(2):790-9.
Development and functional properties of thymic and extrathymic T lymphocytes.Crit. Rev. Immunol. 2008-01-01;28(5):441-66.
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.Breast Cancer Res. 2008-01-01;10(6):R99.
Complementary and independent function for Hoxb4 and Bmi1 in HSC activity.Cold Spring Harb. Symp. Quant. Biol. 2008-01-01;73:555-64.
Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.BMC Cancer 2008-01-01;8:337.
[Towards an "epigenetic" therapy of cancer]Med Sci (Paris) 2008-01-01;24(8-9):671.
Confocal imaging of cell division.Curr Protoc Cytom 2008-01-01;Chapter 12:Unit12.11.
The RSK factors of activating the Ras/MAPK signaling cascade.Front. Biosci. 2008-01-01;13:4258-75.
Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells.Nucleic Acids Res. 2008-01-01;36(1):76-93.
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