IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Killer granzyme B linked to N-myc- and c-myc-dependent HSC survival: isn't that comyc?Sauvageau G, Perreault CCell Stem Cell 2008-12-04;3(6):579-80.

Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay PL, Meloche SJ. Cell. Physiol. 2008-12-01;217(3):778-88.

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.Choo AY, Yoon SO, Kim SG, Roux PP, Blenis JProc. Natl. Acad. Sci. U.S.A. 2008-11-11;105(45):17414-9.

Roux-en-Y diversion for intractable reflux after esophagectomy.D'Journo XB, Martin J, Gaboury L, Ferraro P, Duranceau AAnn. Thorac. Surg. 2008-11-01;86(5):1646-52.

Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis.Matsubayashi J, Takanashi M, Oikawa K, Fujita K, Tanaka M, Xu M, De Blasi A, Bouvier M, Kinoshita M, Kuroda M, Mukai KJ. Pathol. 2008-11-01;216(3):317-27.

Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?Borden KLBiochim. Biophys. Acta 2008-11-01;1783(11):2145-54.

Ribavirin targets eIF4E dependent Akt survival signaling.Tan K, Culjkovic B, Amri A, Borden KLBiochem. Biophys. Res. Commun. 2008-10-24;375(3):341-5.

Evidence for Hox and E2A-PBX1 collaboration in mouse T-cell leukemia.Bijl J, Krosl J, Lebert-Ghali CE, Vacher J, Mayotte N, Sauvageau GOncogene 2008-10-23;27(49):6356-64.

C. elegans Brat homologs regulate PAR protein-dependent polarity and asymmetric cell division.Hyenne V, Desrosiers M, Labbé JCDev. Biol. 2008-09-15;321(2):368-78.

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Thibault P, Roux PPCurr. Biol. 2008-09-09;18(17):1269-77.

Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction.Pontier SM, Percherancier Y, Galandrin S, Breit A, Galés C, Bouvier MJ. Biol. Chem. 2008-09-05;283(36):24659-72.

The IKK-related kinases: from innate immunity to oncogenesis.Clément JF, Meloche S, Servant MJCell Res. 2008-09-01;18(9):889-99.

Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.Tang Y, Holbert MA, Wurtele H, Meeth K, Rocha W, Gharib M, Jiang E, Thibault P, Verreault A, Cole PA, Marmorstein RNat. Struct. Mol. Biol. 2008-09-01;15(9):998.

A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.Gassmann R, Essex A, Hu JS, Maddox PS, Motegi F, Sugimoto A, O'Rourke SM, Bowerman B, McLeod I, Yates JR, Oegema K, Cheeseman IM, Desai AGenes Dev. 2008-09-01;22(17):2385-99.

Comprehensive profiling of histone modifications using a label-free approach and its applications in determining structure-function relationships.Drogaris P, Wurtele H, Masumoto H, Verreault A, Thibault PAnal. Chem. 2008-09-01;80(17):6698-707.

Graft-versus-host disease causes failure of donor hematopoiesis and lymphopoiesis in interferon-gamma receptor-deficient hosts.Delisle JS, Gaboury L, Bélanger MP, Tassé E, Yagita H, Perreault CBlood 2008-09-01;112(5):2111-9.

Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle.Yang G, Cameron LA, Maddox PS, Salmon ED, Danuser GJ. Cell Biol. 2008-08-25;182(4):631-9.

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.Ebralidze AK, Guibal FC, Steidl U, Zhang P, Lee S, Bartholdy B, Jorda MA, Petkova V, Rosenbauer F, Huang G, Dayaram T, Klupp J, O'Brien KB, Will B, Hoogenkamp M, Borden KL, Bonifer C, Tenen DGGenes Dev. 2008-08-01;22(15):2085-92.

Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.Celic I, Verreault A, Boeke JDGenetics 2008-08-01;179(4):1769-84.

Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly.Li Q, Zhou H, Wurtele H, Davies B, Horazdovsky B, Verreault A, Zhang ZCell 2008-07-25;134(2):244-55.

The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling.Louis I, Heinonen KM, Chagraoui J, Vainio S, Sauvageau G, Perreault CImmunity 2008-07-18;29(1):57-67.

Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46.Murzina NV, Pei XY, Zhang W, Sparkes M, Vicente-Garcia J, Pratap JV, McLaughlin SH, Ben-Shahar TR, Verreault A, Luisi BF, Laue EDStructure 2008-07-01;16(7):1077-85.

Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.Tang Y, Holbert MA, Wurtele H, Meeth K, Rocha W, Gharib M, Jiang E, Thibault P, Verreault A, Verrault A, Cole PA, Marmorstein RNat. Struct. Mol. Biol. 2008-07-01;15(7):738-45.

Insights into signaling from the beta2-adrenergic receptor structure.Audet M, Bouvier MNat. Chem. Biol. 2008-07-01;4(7):397-403.

Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.Galandrin S, Oligny-Longpré G, Bonin H, Ogawa K, Galés C, Bouvier MMol. Pharmacol. 2008-07-01;74(1):162-72.

Clothing up DNA for all seasons: Histone chaperones and nucleosome assembly pathways.Rocha W, Verreault AFEBS Lett. 2008-06-18;582(14):1938-49.

NMR assignment of the arenaviral protein Z from Lassa fever virus.Volpon L, Osborne MJ, Borden KLBiomol NMR Assign 2008-06-01;2(1):81-4.

Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins.Audet N, Galés C, Archer-Lahlou E, Vallières M, Schiller PW, Bouvier M, Pineyro GJ. Biol. Chem. 2008-05-30;283(22):15078-88.

Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance.Znaidi S, Weber S, Al-Abdin OZ, Bomme P, Saidane S, Drouin S, Lemieux S, De Deken X, Robert F, Raymond MEukaryotic Cell 2008-05-01;7(5):836-47.

Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes.Thibodeau J, Bourgeois-Daigneault MC, Huppé G, Tremblay J, Aumont A, Houde M, Bartee E, Brunet A, Gauvreau ME, de Gassart A, Gatti E, Baril M, Cloutier M, Bontron S, Früh K, Lamarre D, Steimle VEur. J. Immunol. 2008-05-01;38(5):1225-30.

Polycomb group genes: keeping stem cell activity in balance.Sauvageau M, Sauvageau GPLoS Biol. 2008-04-29;6(4):e113.

The eIF4E RNA regulon promotes the Akt signaling pathway.Culjkovic B, Tan K, Orolicki S, Amri A, Meloche S, Borden KLJ. Cell Biol. 2008-04-07;181(1):51-63.

Fast-tracking steroid receptor crystallization.Mader SNat. Chem. Biol. 2008-04-01;4(4):226-7.

The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila.Bowman SK, Rolland V, Betschinger J, Kinsey KA, Emery G, Knoblich JADev. Cell 2008-04-01;14(4):535-46.

Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme.Bouchard P, Lacroix-Labonté J, Desjardins G, Lampron P, Lisi V, Lemieux S, Major F, Legault PRNA 2008-04-01;14(4):736-48.

Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association.Clément JF, Bibeau-Poirier A, Gravel SP, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJJ. Virol. 2008-04-01;82(8):3984-96.

Modulation of the phagosome proteome by interferon-gamma.Jutras I, Houde M, Currier N, Boulais J, Duclos S, LaBoissière S, Bonneil E, Kearney P, Thibault P, Paramithiotis E, Hugo P, Desjardins MMol. Cell Proteomics 2008-04-01;7(4):697-715.

Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses: application to cell signaling events of interferon-gamma-stimulated macrophages.Marcantonio M, Trost M, Courcelles M, Desjardins M, Thibault PMol. Cell Proteomics 2008-04-01;7(4):645-60.

The MHC class I peptide repertoire is molded by the transcriptome.Fortier MH, Caron E, Hardy MP, Voisin G, Lemieux S, Perreault C, Thibault PJ. Exp. Med. 2008-03-17;205(3):595-610.

The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data.Parisien M, Major FNature 2008-03-06;452(7183):51-5.

Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization.Ouedraogo M, Lecat S, Rochdi MD, Hachet-Haas M, Matthes H, Gicquiaux H, Verrier S, Gaire M, Glasser N, Mély Y, Takeda K, Bouvier M, Galzi JL, Bucher BTraffic 2008-03-01;9(3):305-24.

The effect of covalent cross-links between the membrane components of microcapsules on the dissemination of encapsulated malignant cells.Dusseault J, Langlois G, Meunier MC, Ménard M, Perreault C, Hallé JPBiomaterials 2008-03-01;29(7):917-24.

Newly-isolated HPV97, related to HPV18 and 45 is frequently detected in HIV-positive men from the Montreal area.Gorska-Flipot I, Sawick J, Gaboury LA, Krajinovic M, Labuda D, Brukner I, Rouleau D, Ghattas G, Franco EL, Coutlée FInt. J. Cancer 2008-03-01;122(5):1195-7.

Chromosome segregation: centromeres get bent.Dorn JF, Maddox PSCurr. Biol. 2008-02-26;18(4):R159-61.

CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri FProc. Natl. Acad. Sci. U.S.A. 2008-02-26;105(8):2836-41.

SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.Dammermann A, Maddox PS, Desai A, Oegema KJ. Cell Biol. 2008-02-25;180(4):771-85.

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.Rodier G, Coulombe P, Tanguay PL, Boutonnet C, Meloche SEMBO J. 2008-02-20;27(4):679-91.

Why T cells of thymic versus extrathymic origin are functionally different.Blais ME, Brochu S, Giroux M, Bélanger MP, Dulude G, Sékaly RP, Perreault CJ. Immunol. 2008-02-15;180(4):2299-312.

Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer.Coulon V, Audet M, Homburger V, Bockaert J, Fagni L, Bouvier M, Perroy JBiophys. J. 2008-02-01;94(3):1001-9.

Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia.Sauvageau M, Miller M, Lemieux S, Lessard J, Hébert J, Sauvageau GBlood 2008-01-15;111(2):790-9.

Development and functional properties of thymic and extrathymic T lymphocytes.Heinonen KM, Perreault CCrit. Rev. Immunol. 2008-01-01;28(5):441-66.

Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.Stratford AL, Fry CJ, Desilets C, Davies AH, Cho YY, Li Y, Dong Z, Berquin IM, Roux PP, Dunn SEBreast Cancer Res. 2008-01-01;10(6):R99.

Complementary and independent function for Hoxb4 and Bmi1 in HSC activity.Faubert A, Chagraoui J, Mayotte N, Fréchette M, Iscove NN, Humphries RK, Sauvageau GCold Spring Harb. Symp. Quant. Biol. 2008-01-01;73:555-64.

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.Voisin L, Julien C, Duhamel S, Gopalbhai K, Claveau I, Saba-El-Leil MK, Rodrigue-Gervais IG, Gaboury L, Lamarre D, Basik M, Meloche SBMC Cancer 2008-01-01;8:337.

[Towards an "epigenetic" therapy of cancer]Rocha W, Verreault AMed Sci (Paris) 2008-01-01;24(8-9):671.

Confocal imaging of cell division.Maddox PSCurr Protoc Cytom 2008-01-01;Chapter 12:Unit12.11.

The RSK factors of activating the Ras/MAPK signaling cascade.Carriere A, Ray H, Blenis J, Roux PPFront. Biosci. 2008-01-01;13:4258-75.

Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells.Bourdeau V, Deschênes J, Laperrière D, Aid M, White JH, Mader SNucleic Acids Res. 2008-01-01;36(1):76-93.

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