IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Asynchronous differentiation of CD8 T cells that recognize dominant and cryptic antigens.Baron C, Meunier MC, Caron E, Côté C, Cameron MJ, Kelvin DJ, LeBlanc R, Rineau V, Perreault CJ. Immunol. 2006-12-15;177(12):8466-75.

[Retinoid metabolism and cancer]Parisotto M, Brodeur H, Bhat PV, Mader SMed Sci (Paris) 2006-12-01;22(12):1101-6.

Regulation of p53 localization and activity by Ubc13.Laine A, Topisirovic I, Zhai D, Reed JC, Borden KL, Ronai ZMol. Cell. Biol. 2006-12-01;26(23):8901-13.

Effect of radioactivity on stent-graft incorporation after endovascular treatment of aneurysms: An animal study.Lerouge S, Raymond J, Schloesser K, Gaboury L, Soulez GJ Biomed Mater Res A 2006-12-01;79(3):731-9.

In vitro stem cell expansion: stepping closer towards self-renewal.Cellot S, Sauvageau GGene Ther. 2006-12-01;13(23):1617-8.

Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4.Aberg E, Perander M, Johansen B, Julien C, Meloche S, Keyse SM, Seternes OMJ. Biol. Chem. 2006-11-17;281(46):35499-510.

SP analysis may be used to identify cancer stem cell populations.Hadnagy A, Gaboury L, Beaulieu R, Balicki DExp. Cell Res. 2006-11-15;312(19):3701-10.

eIF4E is a central node of an RNA regulon that governs cellular proliferation.Culjkovic B, Topisirovic I, Skrabanek L, Ruiz-Gutierrez M, Borden KLJ. Cell Biol. 2006-11-06;175(3):415-26.

Histone H3 lysine 56 acetylation: a new twist in the chromosome cycle.Ozdemir A, Masumoto H, Fitzjohn P, Verreault A, Logie CCell Cycle 2006-11-01;5(22):2602-8.

New treatment strategies against hepatitis C viral infection.Bilodeau M, Lamarre DCan. J. Gastroenterol. 2006-11-01;20(11):735-9.

Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.Volpon L, Osborne MJ, Topisirovic I, Siddiqui N, Borden KLEMBO J. 2006-11-01;25(21):5138-49.

Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation.Das C, Hizume K, Batta K, Kumar BR, Gadad SS, Ganguly S, Lorain S, Verreault A, Sadhale PP, Takeyasu K, Kundu TKMol. Cell. Biol. 2006-11-01;26(22):8303-15.

Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy.Galandrin S, Bouvier MMol. Pharmacol. 2006-11-01;70(5):1575-84.

Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.Bibeau-Poirier A, Gravel SP, Clément JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJJ. Immunol. 2006-10-15;177(8):5059-67.

Kinetic properties of chimeric class I aldehyde dehydrogenases for retinal isomers.Brodeur H, Chagnon S, Parisotto M, Mader S, Bhat PVBiochem. Cell Biol. 2006-10-01;84(5):799-804.

[New hopes for cancer immunotherapy].Meunier MC, Delisle JS, Baron C, Perreault CMed Sci (Paris) 2006-10-01;22(10):794-5.

Uncovering stemness.Bilodeau M, Sauvageau GNat. Cell Biol. 2006-10-01;8(10):1048-9.

Mind the GAP: Wnt steps onto the mTORC1 train.Choo AY, Roux PP, Blenis JCell 2006-09-08;126(5):834-6.

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.Galés C, Van Durm JJ, Schaak S, Pontier S, Percherancier Y, Audet M, Paris H, Bouvier MNat. Struct. Mol. Biol. 2006-09-01;13(9):778-86.

A genomewide screen for suppressors of par-2 uncovers potential regulators of PAR protein-dependent cell polarity in Caenorhabditis elegans.Labbé JC, Pacquelet A, Marty T, Gotta MGenetics 2006-09-01;174(1):285-95.

An interview with Michel Bouvier, Ph.D. Interview by Vicki Glaser.Bouvier MAssay Drug Dev Technol 2006-08-01;4(4):365-71.

Implant degradation and poor healing after endovascular repair of abdominal aortic aneurysms: an analysis of explanted stent-grafts.Major A, Guidoin R, Soulez G, Gaboury LA, Cloutier G, Sapoval M, Douville Y, Dionne G, Geelkerken RH, Petrasek P, Lerouge SJ. Endovasc. Ther. 2006-08-01;13(4):457-67.

E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, Sauvageau GGenes Dev. 2006-08-01;20(15):2110-20.

Ribosomal DNA transcription-dependent processes interfere with chromosome segregation.Tomson BN, D'Amours D, Adamson BS, Aragon L, Amon AMol. Cell. Biol. 2006-08-01;26(16):6239-47.

Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling.Breit A, Gagnidze K, Devi LA, Lagacé M, Bouvier MMol. Pharmacol. 2006-08-01;70(2):686-96.

Tamoxifen and raloxifene differ in their functional interactions with aspartate 351 of estrogen receptor alpha.Dayan G, Lupien M, Auger A, Anghel SI, Rocha W, Croisetière S, Katzenellenbogen JA, Mader SMol. Pharmacol. 2006-08-01;70(2):579-88.

Isolation of human prostatic epithelial plasma membranes for proteomics using mirror image tissue banking of radical prostatectomy specimens.Sircar K, Gaboury L, Ouadi L, Mecteau M, Scarlata E, Saad F, Aprikian A, Tanguay S, Lapointe S, Lussier C, Miletti T, Lanoix JClin. Cancer Res. 2006-07-15;12(14 Pt 1):4178-84.

Isolation of human prostatic epithelial plasma membranes for proteomics using mirror image tissue banking of radical prostatectomy specimens.Sircar K, Gaboury L, Ouadi L, Mecteau M, Scarlata E, Saad F, Aprikian A, Tanguay S, Lapointe S, Lussier C, Miletti T, Lanoix JClin. Cancer Res. 2006-07-15;12(14 Pt 1):4178-84.

Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation.Mamo A, Krosl J, Kroon E, Bijl J, Thompson A, Mayotte N, Girard S, Bisaillon R, Beslu N, Featherstone M, Sauvageau GBlood 2006-07-15;108(2):622-9.

The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.Celic I, Masumoto H, Griffith WP, Meluh P, Cotter RJ, Boeke JD, Verreault ACurr. Biol. 2006-07-11;16(13):1280-9.

Integrated microfluidic devices with enhanced separation performance: application to phosphoproteome analyses of differentiated cell model systems.Ghitun M, Bonneil E, Fortier MH, Yin H, Killeen K, Thibault PJ Sep Sci 2006-07-01;29(11):1539-49.

Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells.Rebois RV, Robitaille M, Galés C, Dupré DJ, Baragli A, Trieu P, Ethier N, Bouvier M, Hébert TEJ. Cell. Sci. 2006-07-01;119(Pt 13):2807-18.

Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells.Bijl J, Thompson A, Ramirez-Solis R, Krosl J, Grier DG, Lawrence HJ, Sauvageau GBlood 2006-07-01;108(1):116-22.

Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy.Pontier SM, Lahaie N, Ginham R, St-Gelais F, Bonin H, Bell DJ, Flynn H, Trudeau LE, McIlhinney J, White JH, Bouvier MEMBO J. 2006-06-21;25(12):2698-709.

Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human delta opioid receptor.Petäjä-Repo UE, Hogue M, Leskelä TT, Markkanen PM, Tuusa JT, Bouvier MJ. Biol. Chem. 2006-06-09;281(23):15780-9.

PDR16-mediated azole resistance in Candida albicans.Saidane S, Weber S, De Deken X, St-Germain G, Raymond MMol. Microbiol. 2006-06-01;60(6):1546-62.

Glycosylation of b-Type flagellin of Pseudomonas aeruginosa: structural and genetic basis.Verma A, Schirm M, Arora SK, Thibault P, Logan SM, Ramphal RJ. Bacteriol. 2006-06-01;188(12):4395-403.

Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila.Baril C, Therrien MDev. Biol. 2006-06-01;294(1):232-45.

Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds.García CC, Djavani M, Topisirovic I, Borden KL, Salvato MS, Damonte EBJ. Gen. Virol. 2006-05-01;87(Pt 5):1217-28.

Management of radial scars found at percutaneous breast biopsy.Becker L, Trop I, David J, Latour M, Ouimet-Oliva D, Gaboury L, Lalonde LCan Assoc Radiol J 2006-04-01;57(2):72-8.

New developmental insights from high-throughput biological analysis in Caenorhabditis elegans.Labbé JC, Roy RClin. Genet. 2006-04-01;69(4):306-14.

A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.Douziech M, Sahmi M, Laberge G, Therrien MGenes Dev. 2006-04-01;20(7):807-19.

Identification and characterization of an Xp22.33;Yp11.2 translocation causing a triplication of several genes of the pseudoautosomal region 1 in an XX male patient with severe systemic lupus erythematosus.Chagnon P, Schneider R, Hébert J, Fortin PR, Provost S, Belisle C, Gingras M, Bolduc V, Perreault C, Silverman E, Busque LArthritis Rheum. 2006-04-01;54(4):1270-8.

Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence.Guerry P, Ewing CP, Schirm M, Lorenzo M, Kelly J, Pattarini D, Majam G, Thibault P, Logan SMol. Microbiol. 2006-04-01;60(2):299-311.

Novel insights into the pathogenesis of the Graffi murine leukemia retrovirus.Voisin V, Barat C, Hoang T, Rassart EJ. Virol. 2006-04-01;80(8):4026-37.

The emergence of regulated histone proteolysis.Gunjan A, Paik J, Verreault ACurr. Opin. Genet. Dev. 2006-04-01;16(2):112-8.

Histone post-translational modifications and the response to DNA double-strand breaks.Wurtele H, Verreault ACurr. Opin. Cell Biol. 2006-04-01;18(2):137-44.

The RNA Ontology Consortium: an open invitation to the RNA community.Leontis NB, Altman RB, Berman HM, Brenner SE, Brown JW, Engelke DR, Harvey SC, Holbrook SR, Jossinet F, Lewis SE, Major F, Mathews DH, Richardson JS, Williamson JR, Westhof ERNA 2006-04-01;12(4):533-41.

Monitoring protein-protein interactions in living cells by bioluminescence resonance energy transfer (BRET).Hamdan FF, Percherancier Y, Breton B, Bouvier MCurr Protoc Neurosci 2006-02-01;Chapter 5:Unit 5.23.

T-cell development: an extrathymic perspective.Blais ME, Louis I, Perreault CImmunol. Rev. 2006-02-01;209:103-14.

Convergence of vitamin D and retinoic acid signalling at a common hormone response element.Tavera-Mendoza L, Wang TT, Lallemant B, Zhang R, Nagai Y, Bourdeau V, Ramirez-Calderon M, Desbarats J, Mader S, White JHEMBO Rep. 2006-02-01;7(2):180-5.

ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang TEMBO J. 2006-01-25;25(2):357-66.

Antimony trioxide-induced apoptosis is dependent on SEK1/JNK signaling.Mann KK, Davison K, Colombo M, Colosimo AL, Diaz Z, Padovani AM, Guo Q, Scrivens PJ, Gao W, Mader S, Miller WHToxicol. Lett. 2006-01-05;160(2):158-70.

Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression.Lemieux SBMC Bioinformatics 2006-01-01;7:391.

NMR assignment of human eukaryotic translation initiation factor 4E (eIF4E) in its cap-free form.Volpon L, Osborne MJ, Borden KLJ. Biomol. NMR 2006-01-01;36 Suppl 1:65.

Genome-wide approaches for identification of nuclear receptor target genes.Tavera-Mendoza LE, Mader S, White JH 2006-01-01;4:e018.

Automated extraction and classification of RNA tertiary structure cyclic motifs.Lemieux S, Major FNucleic Acids Res. 2006-01-01;34(8):2340-6.

Evidence that donor intrinsic response to G-CSF is the best predictor of acute graft-vs-host disease following allogeneic peripheral blood stem cell transplantation.Dhédin N, Chamakhi I, Perreault C, Roy DC, Sauvageau G, Ducruet T, Busque L, Fish D, Bélanger R, Roy JExp. Hematol. 2006-01-01;34(1):107-14.

[To apprehend the complexity of living at the era of the < Omics >].Bouvier M, Friedlander GMed Sci (Paris) 2006-01-01;22(1):3-4.

An aplysia dopamine1-like receptor: molecular and functional characterization.Barbas D, Zappulla JP, Angers S, Bouvier M, Mohamed HA, Byrne JH, Castellucci VF, DesGroseillers LJ. Neurochem. 2006-01-01;96(2):414-27.

Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus.Bernier V, Morello JP, Zarruk A, Debrand N, Salahpour A, Lonergan M, Arthus MF, Laperrière A, Brouard R, Bouvier M, Bichet DGJ. Am. Soc. Nephrol. 2006-01-01;17(1):232-43.

Identification of two distinct intracellular localization signals in STT3-B.Caron E, Côté C, Parisien M, Major F, Perreault CArch. Biochem. Biophys. 2006-01-01;445(1):108-14.

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