IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.Drisaldi B, Coomaraswamy J, Mastrangelo P, Strome B, Yang J, Watts JC, Chishti MA, Marvi M, Windl O, Ahrens R, Major F, Sy MS, Kretzschmar H, Fraser PE, Mount HT, Westaway DJ. Biol. Chem. 2004-12-31;279(53):55443-54.

Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.Kentsis A, Topisirovic I, Culjkovic B, Shao L, Borden KLProc. Natl. Acad. Sci. U.S.A. 2004-12-28;101(52):18105-10.

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway.Seternes OM, Mikalsen T, Johansen B, Michaelsen E, Armstrong CG, Morrice NA, Turgeon B, Meloche S, Moens U, Keyse SMEMBO J. 2004-12-08;23(24):4780-91.

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities.Topisirovic I, Ruiz-Gutierrez M, Borden KLCancer Res. 2004-12-01;64(23):8639-42.

Molecular interactions involved in HOXB4-induced activation of HSC self-renewal.Beslu N, Krosl J, Laurin M, Mayotte N, Humphries KR, Sauvageau GBlood 2004-10-15;104(8):2307-14.

Flagellin from Listeria monocytogenes is glycosylated with beta-O-linked N-acetylglucosamine.Schirm M, Kalmokoff M, Aubry A, Thibault P, Sandoz M, Logan SMJ. Bacteriol. 2004-10-01;186(20):6721-7.

Are genetic determinants of asymmetric stem cell division active in hematopoietic stem cells?Faubert A, Lessard J, Sauvageau GOncogene 2004-09-20;23(43):7247-55.

In vitro and in vivo expansion of hematopoietic stem cells.Sauvageau G, Iscove NN, Humphries RKOncogene 2004-09-20;23(43):7223-32.

Genetic programs regulating HSC specification, maintenance and expansion.Lessard J, Faubert A, Sauvageau GOncogene 2004-09-20;23(43):7199-209.

The origin of hematopoietic cell type diversity.Hoang TOncogene 2004-09-20;23(43):7188-98.

N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.Coulombe P, Rodier G, Bonneil E, Thibault P, Meloche SMol. Cell. Biol. 2004-07-01;24(14):6140-50.

Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061.Thibeault D, Bousquet C, Gingras R, Lagacé L, Maurice R, White PW, Lamarre DJ. Virol. 2004-07-01;78(14):7352-9.

Probing genetic variation and glycoform distribution in lectins of the Erythrina genus by mass spectrometry.Bonneil E, Young NM, Lis H, Sharon N, Thibault PArch. Biochem. Biophys. 2004-06-15;426(2):241-9.

Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.Zhang D, Bar-Eli M, Meloche S, Brodt PJ. Biol. Chem. 2004-05-07;279(19):19683-90.

Peptide-based inhibitors of the hepatitis C virus NS3 protease: structure-activity relationship at the C-terminal position.Rancourt J, Cameron DR, Gorys V, Lamarre D, Poirier M, Thibeault D, Llinàs-Brunet MJ. Med. Chem. 2004-05-06;47(10):2511-22.

Structural and genetic characterization of glycosylation of type a flagellin in Pseudomonas aeruginosa.Schirm M, Arora SK, Verma A, Vinogradov E, Thibault P, Ramphal R, Logan SMJ. Bacteriol. 2004-05-01;186(9):2523-31.

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.Lips DJ, Bueno OF, Wilkins BJ, Purcell NH, Kaiser RA, Lorenz JN, Voisin L, Saba-El-Leil MK, Meloche S, Pouysségur J, Pagès G, De Windt LJ, Doevendans PA, Molkentin JDCirculation 2004-04-27;109(16):1938-41.

Do thymically and strictly extrathymically developing T cells generate similar immune responses?Blais ME, Gérard G, Martinic MM, Roy-Proulx G, Zinkernagel RM, Perreault CBlood 2004-04-15;103(8):3102-10.

Structure-activity study on a novel series of macrocyclic inhibitors of the hepatitis C virus NS3 protease leading to the discovery of BILN 2061.Llinàs-Brunet M, Bailey MD, Bolger G, Brochu C, Faucher AM, Ferland JM, Garneau M, Ghiro E, Gorys V, Grand-Maître C, Halmos T, Lapeyre-Paquette N, Liard F, Poirier M, Rhéaume M, Tsantrizos YS, Lamarre DJ. Med. Chem. 2004-03-25;47(7):1605-8.

Erk2 signaling and early embryo stem cell self-renewal.Meloche S, Vella FD, Voisin L, Ang SL, Saba-El-Leil MCell Cycle 2004-03-01;3(3):241-3.

Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia.Ferrando AA, Herblot S, Palomero T, Hansen M, Hoang T, Fox EA, Look ATBlood 2004-03-01;103(5):1909-11.

SCL assembles a multifactorial complex that determines glycophorin A expression.Lahlil R, Lécuyer E, Herblot S, Hoang TMol. Cell. Biol. 2004-02-01;24(4):1439-52.

SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis.Martin R, Lahlil R, Damert A, Miquerol L, Nagy A, Keller G, Hoang TDevelopment 2004-02-01;131(3):693-702.

Molecular basis for stem-cell self-renewal.Krosl JK, Faubert A, Sauvageau GHematol. J. 2004-01-01;5 Suppl 3:S118-21.

Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.McKercher G, Beaulieu PL, Lamarre D, LaPlante S, Lefebvre S, Pellerin C, Thauvette L, Kukolj GNucleic Acids Res. 2004-01-01;32(2):422-31.

SCL: from the origin of hematopoiesis to stem cells and leukemia.Lécuyer E, Hoang TExp. Hematol. 2004-01-01;32(1):11-24.

NMR structural characterization of peptide inhibitors bound to the Hepatitis C virus NS3 protease: design of a new P2 substituent.Goudreau N, Cameron DR, Bonneau P, Gorys V, Plouffe C, Poirier M, Lamarre D, Llinas-Brunet MJ. Med. Chem. 2004-01-01;47(1):123-32.

Hepatitis C virus subgenomic replicons in the human embryonic kidney 293 cell line.Ali S, Pellerin C, Lamarre D, Kukolj GJ. Virol. 2004-01-01;78(1):491-501.

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