IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.Lamarre D, Anderson PC, Bailey M, Beaulieu P, Bolger G, Bonneau P, Bös M, Cameron DR, Cartier M, Cordingley MG, Faucher AM, Goudreau N, Kawai SH, Kukolj G, Lagacé L, LaPlante SR, Narjes H, Poupart MA, Rancourt J, Sentjens RE, St George R, Simoneau B, Steinmann G, Thibeault D, Tsantrizos YS, Weldon SM, Yong CL, Llinàs-Brunet MNature 2003-11-13;426(6963):186-9.

In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein.Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, Sauvageau GNat. Med. 2003-11-01;9(11):1428-32.

Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression.Julien C, Coulombe P, Meloche SJ. Biol. Chem. 2003-10-24;278(43):42615-24.

Phosphorylation of the MAPKKK regulator Ste50p in Saccharomyces cerevisiae: a casein kinase I phosphorylation site is required for proper mating function.Wu C, Arcand M, Jansen G, Zhong M, Iouk T, Thomas DY, Meloche S, Whiteway MEukaryotic Cell 2003-10-01;2(5):949-61.

Bimodal regulation of RAF by CNK in Drosophila.Douziech M, Roy F, Laberge G, Lefrançois M, Armengod AV, Therrien MEMBO J. 2003-10-01;22(19):5068-78.

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche SEMBO Rep. 2003-10-01;4(10):964-8.

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.Levantini E, Giorgetti A, Cerisoli F, Traggiai E, Guidi A, Martin R, Acampora D, Aplan PD, Keller G, Simeone A, Iscove NN, Hoang T, Magli MCProc. Natl. Acad. Sci. U.S.A. 2003-09-02;100(18):10299-303.

Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis.Lessard J, Sauvageau GExp. Hematol. 2003-07-01;31(7):567-85.

Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.Coulombe P, Rodier G, Pelletier S, Pellerin J, Meloche SMol. Cell. Biol. 2003-07-01;23(13):4542-58.

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