IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression.Larouche M, Kachaner D, Wang P, Normandin K, Garrido D, Yao C, Cormier M, Johansen KM, Johansen J, Archambault VJ Cell Biol 2021-06-07;220(6).

Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CCNat Commun 2021-04-30;12(1):2482.

1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C).Osborne MJ, Rahardjo AK, Volpon L, Borden KLBBiomol NMR Assign 2021-04-18.

Heritable variation in telomere length predicts mortality in Soay sheep.Froy H, Underwood SL, Dorrens J, Seeker LA, Watt K, Wilbourn RV, Pilkington JG, Harrington L, Pemberton JM, Nussey DHProc Natl Acad Sci U S A 2021-04-13;118(15).

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Thériault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, Hébert J, Sauvageau G, Lemieux S, Thibault P, Perreault CImmunity 2021-04-13;54(4):737-752.e10.

Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7.Meyrath M, Palmer CB, Reynders N, Vanderplasschen A, Ollert M, Bouvier M, Szpakowska M, Chevigné AACS Pharmacol Transl Sci 2021-04-09;4(2):813-823.

Penile Cancer-Derived Cells Molecularly Characterized as Models to Guide Targeted Therapies.Kuasne H, Canto LMD, Aagaard MM, Muñoz JJM, Jamblinne C, Marchi FA, Scapulatempo-Neto C, Faria EF, Lopes A, Carréno S, Rogatto SRCells 2021-04-06;10(4).

Development of conformational BRET biosensors that monitor ezrin, radixin and moesin activation in real time.Leguay K, Decelle B, He YY, Pagniez A, Hogue M, Kobayashi H, Le Gouill C, Bouvier M, Carréno SJ Cell Sci 2021-04-01;134(7).

SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.MacNeil DE, Lambert-Lanteigne P, Qin J, McManus FP, Bonneil E, Thibault P, Autexier CMol Cell Biol 2021-03-24;41(4).

Interleukin-17 Receptor D in Physiology, Inflammation and Cancer.Girondel C, Meloche SFront Oncol 2021-03-23;11:656004.

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński JCell Rep 2021-03-23;34(12):108862.

TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation.Connolly A, Panes R, Tual M, Lafortune R, Bellemare-Pelletier A, Gagnon ESci Signal 2021-03-23;14(675).

Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair.Moison C, Chagraoui J, Caron MC, Gagné JP, Coulombe Y, Poirier GG, Masson JY, Sauvageau GProc Natl Acad Sci U S A 2021-03-16;118(11).

Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.Grunddal KV, Diep TA, Petersen N, Tough IR, Skov LJ, Liu L, Buijink JA, Mende F, Jin C, Jepsen SL, Sørensen LME, Achiam MP, Strandby RB, Bach A, Hartmann B, Frimurer TM, Hjorth SA, Bouvier M, Cox H, Holst BMol Metab 2021-03-09:101207.

Most non-canonical proteins uniquely populate the proteome or immunopeptidome.Ruiz Cuevas MV, Hardy MP, Hollý J, Bonneil E, Durette C, Courcelles M, Lanoix J, Côté C, Staudt LM, Lemieux S, Thibault P, Perreault C, Yewdell JWCell Rep 2021-03-09;34(10):108815.

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.Benslimane Y, Sánchez-Osuna M, Coulombe-Huntington J, Bertomeu T, Henry D, Huard C, Bonneil E, Thibault P, Tyers M, Harrington LAging Cell 2021-03-04:e13331.

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.Gargalovic P, Wong P, Onorato J, Finlay H, Wang T, Yan M, Crain E, St-Onge S, Héroux M, Bouvier M, Xu C, Chen XQ, Generaux C, Lawrence M, Wexler R, Gordon DCirc Heart Fail 2021-03-01;14(3):e007351.

The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.Blondel-Tepaz E, Leverve M, Sokrat B, Paradis JS, Kosic M, Saha K, Auffray C, Lima-Fernandes E, Zamborlini A, Poupon A, Gaboury L, Findlay J, Baillie GS, Enslen H, Bouvier M, Angers S, Marullo S, Scott MGHOncogene 2021-03-01;40(12):2243-2257.

p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors.Cañedo EC, Totten S, Ahn R, Savage P, MacNeil D, Hudson J, Autexier C, Deblois G, Park M, Witcher M, Ursini-Siegel JJCI Insight 2021-02-22;6(4).

Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.René P, Lanfray D, Richard D, Bouvier MJCI Insight 2021-02-22;6(4).

Feedback control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish.Tschaikner PM, Regele D, Röck R, Salvenmoser W, Meyer D, Bouvier M, Geley S, Stefan E, Aanstad PDevelopment 2021-02-17;148(4).

PRMT5 inhibition disrupts splicing and stemness in glioblastoma.Sachamitr P, Ho JC, Ciamponi FE, Ba-Alawi W, Coutinho FJ, Guilhamon P, Kushida MM, Cavalli FMG, Lee L, Rastegar N, Vu V, Sánchez-Osuna M, Coulombe-Huntington J, Kanshin E, Whetstone H, Durand M, Thibault P, Hart K, Mangos M, Veyhl J, Chen W, Tran N, Duong BC, Aman AM, Che X, Lan X, Whitley O, Zaslaver O, Barsyte-Lovejoy D, Richards LM, Restall I, Caudy A, Röst HL, Bonday ZQ, Bernstein M, Das S, Cusimano MD, Spears J, Bader GD, Pugh TJ, Tyers M, Lupien M, Haibe-Kains B, Artee Luchman H, Weiss S, Massirer KB, Prinos P, Arrowsmith CH, Dirks PBNat Commun 2021-02-12;12(1):979.

Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.Trân K, Van Den Hauwe R, Sainsily X, Couvineau P, Côté J, Simard L, Echevarria M, Murza A, Serre A, Théroux L, Saibi S, Haroune L, Longpré JM, Lesur O, Auger-Messier M, Spino C, Bouvier M, Sarret P, Ballet S, Marsault EJ Med Chem 2021-02-01.

Sustained ERK1/2 signaling is necessary for follicular rupture during ovulation in mice.Madogwe E, Schuermann Y, Siddappa D, Bordignon V, Roux PP, Duggavathi RReproduction 2021-02-01;161(2):183-193.

CentTracker: a trainable, machine learning-based tool for large-scale analyses of C. elegans germline stem cell mitosis.Zellag RM, Zhao Y, Poupart V, Singh R, Labbé JC, Gerhold ARMol Biol Cell 2021-01-27:mbcE20110716.

Graphene field-effect transistors as bioanalytical sensors: design, operation and performance.Béraud A, Sauvage M, Bazán CM, Tie M, Bencherif A, Bouilly DAnalyst 2021-01-21;146(2):403-428.

Survival Impact of Aggressive Treatment and PD-L1 Expression in Oligometastatic NSCLC.Gauvin C, Krishnan V, Kaci I, Tran-Thanh D, Bédard K, Albadine R, Leduc C, Gaboury L, Blais N, Tehfe M, Routy B, Florescu MCurr Oncol 2021-01-20;28(1):593-605.

Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.Trân K, Murza A, Sainsily X, Delile E, Couvineau P, Côté J, Coquerel D, Peloquin M, Auger-Messier M, Bouvier M, Lesur O, Sarret P, Marsault EJ Med Chem 2021-01-14;64(1):602-615.

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.Chagraoui J, Girard S, Spinella JF, Simon L, Bonneil E, Mayotte N, MacRae T, Coulombe-Huntington J, Bertomeu T, Moison C, Tomellini E, Thibault P, Tyers M, Marinier A, Sauvageau GCell Stem Cell 2021-01-07;28(1):48-62.e6.

Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.Girondel C, Lévesque K, Langlois MJ, Pasquin S, Saba-El-Leil MK, Rivard N, Friesel R, Servant MJ, Gauchat JF, Lesage S, Meloche SOncogene 2021-01-01;40(2):452-464.

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.Oughtred R, Rust J, Chang C, Breitkreutz BJ, Stark C, Willems A, Boucher L, Leung G, Kolas N, Zhang F, Dolma S, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers MProtein Sci 2021-01-01;30(1):187-200.

UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections.Dumont-Lagacé M, Li Q, Tanguay M, Chagraoui J, Kientega T, Cardin GB, Brasey A, Trofimov A, Carli C, Ahmad I, Bambace NM, Bernard L, Kiss TL, Roy J, Roy DC, Lemieux S, Perreault C, Rodier F, Dufresne SF, Busque L, Lachance S, Sauvageau G, Cohen S, Delisle JSTransplant Cell Ther 2021-01-01;27(1):76.e1-76.e9.

Harnessing tRNA for Processing Ability and Promoter Activity.Knapp DJHF, Fulga TAMethods Mol Biol 2021-01-01;2162:89-114.

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