IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry.Leguay K, Decelle B, Elkholi IE, Bouvier M, Côté JF, Carréno SJ Cell Biol 2022-06-06;221(6)::e202109065.

The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor.Litsios A, Goswami P, Terpstra HM, Coffin C, Vuillemenot LA, Rovetta M, Ghazal G, Guerra P, Buczak K, Schmidt A, Tollis S, Tyers M, Royer CA, Milias-Argeitis A, Heinemann MMol Biol Cell 2022-05-01;33(5):rp2.

Functional diversity in the RAS subfamily of small GTPases.Bernal Astrain G, Nikolova M, Smith MJBiochem Soc Trans 2022-04-29;50(2):921-933.

SUN2 Modulates the Propagation of HSV-1.Cruz-Palomar K, Hawkins J, Vandal C, Quenneville J, Gagnon E, Lippé RJ Virol 2022-04-18:e0045322.

Dynamic Gate Control of Aryldiazonium Chemistry on Graphene Field-Effect Transistors.Bazán CM, Béraud A, Nguyen M, Bencherif A, Martel R, Bouilly DNano Lett 2022-04-13;22(7):2635-2642.

Directing with restraint: Mechanisms of protrusion restriction in collective cell migrations.Roberto GM, Emery GSemin Cell Dev Biol 2022-04-06.

The spindle assembly checkpoint and the spatial activation of Polo kinase determine the duration of cell division and prevent tumor formation.Gallaud E, Richard-Parpaillon L, Bataillé L, Pascal A, Métivier M, Archambault V, Giet RPLoS Genet 2022-04-01;18(4):e1010145.

ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation.Soulez M, Tanguay PL, Dô F, Dort J, Crist C, Kotlyarov A, Gaestel M, Ferron M, Dumont NA, Meloche SJ Cell Physiol 2022-04-01;237(4):2271-2287.

Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability.Cleyle J, Hardy MP, Minati R, Courcelles M, Durette C, Lanoix J, Laverdure JP, Vincent K, Perreault C, Thibault PMol Cell Proteomics 2022-03-31:100228.

Development of a high-throughput assay to identify inhibitors of the ubiquitin-conjugating enzyme UBCH10.Cléroux P, Voisin L, Meloche SSLAS Discov 2022-03-25.

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation.Heckel E, Cagnone G, Agnihotri T, Cakir B, Das A, Kim JS, Kim N, Lavoie G, Situ A, Pundir S, Sun Y, Wünnemann F, Pierce KA, Dennis C, Mitchell GA, Chemtob S, Rezende FA, Andelfinger G, Clish CB, Roux PP, Sapieha P, Smith LE, Joyal JSJCI Insight 2022-03-22;7(6).

Common coupling map advances GPCR-G protein selectivity.Hauser AS, Avet C, Normand C, Mancini A, Inoue A, Bouvier M, Gloriam DEElife 2022-03-18;11:e74107.

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.Avet C, Mancini A, Breton B, Le Gouill C, Hauser AS, Normand C, Kobayashi H, Gross F, Hogue M, Lukasheva V, St-Onge S, Carrier M, Héroux M, Morissette S, Fauman EB, Fortin JP, Schann S, Leroy X, Gloriam DE, Bouvier MElife 2022-03-18;11:e74101.

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion.Tollis S, Rizzotto A, Pham NT, Koivukoski S, Sivakumar A, Shave S, Wildenhain J, Zuleger N, Keys JT, Culley J, Zheng Y, Lammerding J, Carragher NO, Brunton VG, Latonen L, Auer M, Tyers M, Schirmer ECACS Chem Biol 2022-03-18;17(3):680-700.

UM171 expansion of cord blood improves donor availability and HLA matching for all patients, including minorities.Dumont-Lagacé M, Feghaly A, Meunier MC, Finney M, Van't Hof W, Frenet EM, Sauvageau G, Cohen STransplant Cell Ther 2022-03-17.

CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells.Ansari U, Tomellini E, Chagraoui J, Lehnertz B, Mayotte N, Bordeleau ME, Roux PP, Sauvageau GBlood Adv 2022-03-14.

CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia.He L, Arnold C, Thoma J, Rohde C, Kholmatov M, Garg S, Hsiao CC, Viol L, Zhang K, Sun R, Schmidt C, Janssen M, MacRae T, Huber K, Thiede C, Hébert J, Sauvageau G, Spratte J, Fluhr H, Aust G, Müller-Tidow C, Niehrs C, Pereira G, Hamann J, Tanaka M, Zaugg JB, Pabst CEMBO Mol Med 2022-03-07:e14990.

The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.Tollis S, Singh J, Palou R, Thattikota Y, Ghazal G, Coulombe-Huntington J, Tang X, Moore S, Blake D, Bonneil E, Royer CA, Thibault P, Tyers MPLoS Biol 2022-03-01;20(3):e3001548.

Regulation of MHC Class I Expression in Lung Epithelial Cells during Inflammation.Mathé J, Benhammadi M, Kobayashi KS, Brochu S, Perreault CJ Immunol 2022-03-01;208(5):1021-1033.

Real-World Outcomes of Autologous and Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed/Refractory Hodgkin Lymphoma in the Era of Novel Therapies: A Canadian Perspective.Veilleux O, Claveau JS, Alaoui H, Roy J, Ahmad I, Delisle JS, Kiss T, Bambace NM, Bernard L, Cohen S, Sauvageau G, Fleury I, Mollica L, Roy DC, Serroukh Y, Lachance STransplant Cell Ther 2022-03-01;28(3):145-151.

The molecular origin of the electrostatic gating of single-molecule field-effect biosensors investigated by molecular dynamics simulations.Côté S, Bouilly D, Mousseau NPhys Chem Chem Phys 2022-02-16;24(7):4174-4186.

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.Jiang Z, Li H, Schroer SA, Voisin V, Ju Y, Pacal M, Erdmann N, Shi W, Chung PED, Deng T, Chen NJ, Ciavarra G, Datti A, Mak TW, Harrington L, Dick FA, Bader GD, Bremner R, Woo M, Zacksenhaus EEMBO J 2022-02-15;41(4):e106825.

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes.Beillevaire D, Migneault F, Turgeon J, Gingras D, Rimbaud AK, Marcoux G, Spino C, Thibodeau N, Bonneil E, Thibault P, Boilard E, Dieudé M, Hébert MJCell Death Dis 2022-02-11;13(2):145.

Community Guidelines for GPCR Ligand Bias: IUPHAR Review XX.Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov K, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, Shukla AK, Sommer ME, Gloriam DEBr J Pharmacol 2022-02-01.

Outcomes in newly diagnosed young or high-risk myeloma patients receiving tandem autologous/allogeneic transplant followed by bortezomib maintenance: a phase II study.LeBlanc R, Ahmad I, Terra R, Boudreault JS, Ogez D, Lamore K, Delisle JS, Bambace N, Bernard L, Cohen S, Kiss T, Lachance S, Landais S, Lemieux-Blanchard E, Sauvageau G, Sebag M, Roy DC, Roy JBone Marrow Transplant 2022-02-01;57(2):252-260.

Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.Krosl J, Bordeleau ME, Moison C, MacRae T, Boivin I, Mayotte N, Gracias D, Baccelli I, Lavallée VP, Bisaillon R, Lehnertz B, Mendoza-Sanchez R, Ruel R, Bertomeu T, Coulombe-Huntington J, Boucher G, Noronha N, Pabst C, Tyers M, Gendron P, Lemieux S, Barabé F, Marinier A, Hébert J, Sauvageau GBlood Adv 2022-01-25;6(2):509-514.

Signaling by the tyrosine kinase Yes promotes liver cancer development.Guégan JP, Lapouge M, Voisin L, Saba-El-Leil MK, Tanguay PL, Lévesque K, Brégeon J, Mes-Masson AM, Lamarre D, Haibe-Kains B, Trinh VQ, Soucy G, Bilodeau M, Meloche SSci Signal 2022-01-18;15(717):eabj4743.

Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy E, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault E, Boudreault PL, Sarret PJ Med Chem 2022-01-13;65(1):531-551.

Identification and Characterization of the Interaction Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E.Osborne MJ, Volpon L, Memarpoor-Yazdi M, Pillay S, Thambipillai A, Czarnota S, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Cowling VH, Borden KLBJ Mol Biol 2022-01-10;434(5):167451.

Subcellular Fractionation Suitable for Studies of RNA and Protein Trafficking.Culjkovic-Kraljacic B, Borden KLBMethods Mol Biol 2022-01-01;2502:91-104.

Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.Veiga DFT, Tremblay M, Gerby B, Herblot S, Haman A, Gendron P, Lemieux S, Zúñiga-Pflücker JC, Hébert J, Cohen JP, Hoang TFront Immunol 2022-01-01;13:867443.

Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time.Duarte DA, Parreiras-E-Silva LT, Oliveira EB, Bouvier M, Costa-Neto CMHypertension 2022-01-01;79(1):115-125.

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis.Milan T, Celton M, Lagacé K, Roques E, Safa-Tahar-Henni S, Bresson E, Bergeron A, Hebert J, Meshinchi S, Cellot S, Barabé F, Wilhelm BTHaematologica 2022-01-01;107(1):86-99.

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