IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Cross-talk between SUMOylation and ISGylation in response to interferon.El-Asmi F, McManus FP, Brantis-de-Carvalho CE, Valle-Casuso JC, Thibault P, Chelbi-Alix MKCytokine 2020-02-17;129:155025.

Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility.Li C, McManus FP, Plutoni C, Pascariu CM, Nelson T, Alberici Delsin LE, Emery G, Thibault PNat Commun 2020-02-14;11(1):834.

Proteogenomics uncovers a vast repertoire of shared tumor-specific antigens in ovarian cancer.Zhao Q, Laverdure JP, Lanoix J, Durette C, Coté C, Bonneil E, Laumont CM, Gendron P, Vincent K, Courcelles M, Lemieux S, Millar DG, Ohashi PS, Thibault P, Perreault CCancer Immunol Res 2020-02-12.

Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration.Dumont-Lagacé M, Daouda T, Depoërs L, Zumer J, Benslimane Y, Brochu S, Harrington L, Lemieux S, Perreault CFront Immunol 2020-02-11;10:3118.

Beta-arrestins operate an on/off control switch for focal adhesion kinase activity.Alexander RA, Lot I, Saha K, Abadie G, Lambert M, Decosta E, Kobayashi H, Beautrait A, Borrull A, Asnacios A, Bouvier M, Scott MGH, Marullo S, Enslen HCell. Mol. Life Sci. 2020-02-10.

Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau GLancet Haematol 2020-01-31;7(2):e134-e145.

F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.Serres MP, Samwer M, Truong Quang BA, Lavoie G, Perera U, Görlich D, Charras G, Petronczki M, Roux PP, Paluch EKDev. Cell 2020-01-29;52(2):210-222.e7.

Kinesin Kif2C in regulation of DNA double strand break dynamics and repair.Zhu S, Paydar M, Wang F, Li Y, Wang L, Barrette B, Bessho T, Kwok BH, Peng AElife 2020-01-21;9.

The Genomic Landscape of Antigenic Targets for T Cell-Based Leukemia Immunotherapy.Hardy MP, Vincent K, Perreault CFront Immunol 2020-01-13;10:2934.

Conditional switching of KIF2A mutation provides new insights into cortical malformations pathogeny.Gilet J, Ivanova E, Trofimova D, Rudolf G, Meziane H, Broix L, Drouot N, Courraud J, Skory V, Voulleminot P, Osipenko M, Bahi-Buisson N, Yalcin B, Birling MC, Hinckelmann MV, Kwok BH, Allingham JS, Chelly JHum. Mol. Genet. 2020-01-10.

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