Vincent Archambault, Ph.D.

Awards & Honours

  • GE Healthcare New Investigator Award, 2015
  • Maud Menten New Principal Investigator Prize in the Biomedical Research field from the Institute of Genetics of the Canadian Institutes of Health Research, 2009
  • Long-Term Fellowship, Human Frontier Science Program, 2005-2009
  • Long-Term Fellowship, European Molecular Biology Organization (EMBO), 2004-2005

Training

  • Postdoctoral training with David M. Glover, Department of Genetics, University of Cambridge, 2004-2009
  • Ph.D. Biological Sciences with Frederick R. Cross and Michael P. Rout, The Rockefeller University, 1999-2004
  • B.Sc. in Biochemistry, Université de Montréal, 1996-1999

Research Support

  • Canada Foundation for Innovation
  • Canadian Institutes of Health Research
  • Fonds pour la recherche en santé du Québec
  • Human Frontier Science Program
  • Natural Sciences and Engineering Research Council

After completing his undergraduate studies in Biochemistry at the Université de Montréal, Vincent Archambault undertook his Ph.D. at The Rockefeller University in New York City, where he became interested in the fundamental molecular mechanisms that control cell cycle progression. Specifically, he studied how regulation of the cyclin-dependent kinase (Cdk1) by cyclins allows the coordination of cell cycle events in the budding yeast. His interest in studying the cell cycle in the context of a metazoan model took him to the lab of David Glover in the Department of Genetics at the University of Cambridge, UK, as an EMBO fellow and subsequently as a HFSP fellow. Using the versatile Drosophila model, Dr. Archambault studied regulators of cell division, both in the context of the whole animal and in cultured cells, combining genetics, functional genomics, biochemistry, proteomics and microscopy. In particular, he investigated the functions and regulation of two mitotic kinases: Greatwall and Polo. The human ortholog of Polo, Polo-like kinase 1 is overexpressed in many forms of cancer, has oncogenic properties, and is the target of recently developed anti-cancer drugs. Thus it is crucial to understand how these kinases are controlled and function during the cell cycle and in development. Vincent Archambault’s work will contribute to our understanding of the molecular basis of cell division, which is often deregulated in cancer.

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