Trang Hoang, Ph.D.

Awards & Honours

  • Murray Margarit Memorial Award, Leukemia and Lymphoma Society of Canada, 2010
  • Teaching Excellence Award for the creation of the Systems Biology option, Faculty of Medicine, Université de Montréal, 2010 (collective prize shared with Sylvie Mader, Martine Raymond and IRIC researchers)
  • Canada Research Chair in Cell Differentiation and the Genetics of Acute Leukemias, 2004–2011
  • Senior Scholar, Fonds de recherche en santé du Québec, 1994-1997
  • Exchange Scientist, National Cancer Institute, National Institutes of Health, U.S.A., 1992-1993
  • Scholar, National Cancer Institute of Canada, 1987-1993
  • Postdoctoral Fellow, Leukemia Research Fund, U.K, 1982
  • Postdoctoral Fellowship, European Molecular Biology Organization, 1980-1982
  • Scholar, Fonds de recherche sur les lymphomes malins, 1976-1980

Training

  • Postdoctoral training with E. A. McCulloch, Ontario Cancer Institute, Toronto, 1983-1985
  • Postdoctoral training with H. Waldman, University of Cambridge, U.K., 1980-1982
  • Ph.D. cum laude with N.N. Iscove, University of Lausanne, 1980
  • Certificate in biochemistry, University of Lausanne, 1975
  • Diploma in pharmacy practice, University of Lausanne, 1972

Research support

  • Cole Foundation
  • Canadian Cancer Society Research Institute
  • Canadian Institutes of Health Research
  • Leukemia and Lymphoma Society of Canada
  • Soutien à des initiatives internationales de recherche et d’innovation (SIIRI), Ministère du développement économique, innovation et exportation du Québec
  • Fonds de recherche du Québec – Santé

Trang Hoang and her team established for the first time that the collaboration between three oncogenes, SCL, LMO1 and NOTCH1 with a signaling pathway, the pre-TCR, are enough to turn normal pro-thymocytes into leukemic stem cells. Indeed, her early research showed that leukemia cells, despite their uniform appearance, are actually organized in a hierarchy, in which a rare subpopulation of precursors is responsible for maintaining all leukemia cells, thus establishing the foundations for the concept of leukemic stem cells, now considered as promising therapeutic targets. Her current work is to define the molecular mechanisms by which oncogenes disrupt molecular networks in hematopoietic cells, thus inducing a pre-leukemic state and progression to leukemia.

Having always privileged a multidisciplinary approach, Trang Hoang continues to exercise a leading role in establishing collaborations that allow scientists from different disciplines to team up in joint projects. She is a founding member of the Institute for Research in Immunology and Cancer (IRIC) where she heads the research unit in hematopoiesis and leukemia.

In addition to her research, she is very involved in training students and postdoctoral fellows who are the scientists of tomorrow, through the personal supervision she provides as much as through her activities as Director of the graduate studies Program in Molecular Biology, Faculty of Medicine, Université de Montréal. In addition, she serves on the Executive Board of the Fonds de Recherche du Québec – Santé.

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