Signalling and Cell Growth

The expansion of cell populations is a strictly controlled process that results from the balance between cell division and cell death. In multi-cellular organisms, individual cells continuously monitor their external environment for nutrient availability and signals (mitogens, trophic factors, stress) to decide whether to self-renew, proliferate, differentiate or die. Wrong interpretation of these signals may lead to cancer.

The laboratory of Sylvain Meloche uses an interdisciplinary approach that includes biochemistry, cell biology, mouse genetics and chemical biology to understand how signaling pathways control cell fate of normal and cancer cells. Defining the importance and interconnection of these signaling events will further our understanding of the malignant transformation process and aid in the identification of new target molecules for the therapy of cancer.

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