Philippe P. Roux, Ph.D.
Awards & Honours
- GE Healthcare New Investigator Award, 2013
- Canada Research Chair in Signal Transduction and Proteomics, 2006-2016
- Career Development Award, Human Frontier Science Program, 2007-2010
- Long-term Fellowship, Human Frontier Science Program, 2003-2006
- Postdoctoral Fellowship, Canadian Institutes of Health Research, 2002-2003
- Dean’s Honour List for Doctoral Thesis, Faculty of Medicine, McGill University, 2002
- Doctoral Award, Canadian Institutes of Health Research, 1999-2002
- Doctoral Award, Neuroscience Canada Foundation, 1998-1999
- Doctoral Award, Jean Timmons Costello Foundation, 1997-1998
- Studentship, Quebec Social Services Council, 1995-1997
- Postdoctoral training with John Blenis, Department of Cell Biology, Harvard Medical School, 2002-2006
- Ph.D. in Molecular Neurosciences with Phil Barker and Tim Kennedy, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 2002
- M.Sc. in Microbiology and Immunology with Caroline Alfieri and Jerome Tanner, Department of Microbiology and Immunology, University of Montreal, 1997
- Canada Foundation for Innovation
- Canadian Institutes of Health Research
- Canadian Cancer Society Research Institute
- Human Frontier Science Program
- Cancer Research Society
When Philippe Roux began his doctoral studies at the Montreal Neurological Institute of McGill University in 1997, he was particularly interested in the signal transduction pathways implicated in the regulation of neuronal survival and apoptosis. He chose to investigate the signalling mechanisms initiated by the atypical growth factor receptor p75NTR and found that this protein regulates both cell faiths depending on the cellular context. Dr. Roux also used mouse and rat models of excitatory seizures to assess the role of p75NTR in vivo. His studies demonstrated a tight correlation between induced p75NTR expression and neuronal apoptosis, suggesting that this receptor regulates neuronal cell fate in response to trauma within the central nervous system.
In a quest for thorough training in signal transduction, Philippe Roux joined the group of Dr. John Blenis in the Department of Cell Biology of Harvard Medical School in Boston. He was funded by the Canadian Institutes of Health Research and was awarded the prestigious Long-Term Fellowship from the Human Frontier Science Program Organization (2003-2006) to accomplish this phase of his career. His work there focused on the MAP kinase signalling pathway and the mechanisms by which mitogenic cues promote cell growth and proliferation. While studying the evolutionarily conserved RSK family of protein kinases, he made important discoveries on the regulation these enzymes as well as their role in cell growth control through the identification of novel RSK substrates.
Philippe Roux returned to Canada in 2006 to begin work as a principal investigator at IRIC. He was awarded the Canada Research Chair in Signal Transduction and Proteomics.