Publications

Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy E, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault E, Boudreault PL, Sarret PJ Med Chem 2022-01-13;65(1):531-551.

Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time.Duarte DA, Parreiras-E-Silva LT, Oliveira EB, Bouvier M, Costa-Neto CMHypertension 2022-01-01;79(1):115-125.

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs.Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu FCell Res 2021-12-01;31(12):1311-1314.

GPCR activation mechanisms across classes and macro/microscales.Hauser AS, Kooistra AJ, Munk C, Heydenreich FM, Veprintsev DB, Bouvier M, Babu MM, Gloriam DENat Struct Mol Biol 2021-11-01;28(11):879-888.

Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.Hegron A, Huh E, Deupi X, Sokrat B, Gao W, Le Gouill C, Canouil M, Boissel M, Charpentier G, Roussel R, Balkau B, Froguel P, Plouffe B, Bonnefond A, Lichtarge O, Jockers R, Bouvier MACS Pharmacol Transl Sci 2021-10-08;4(5):1614-1627.

Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation.Mansour A, Nagi K, Dallaire P, Lukasheva V, Le Gouill C, Bouvier M, Pineyro GACS Pharmacol Transl Sci 2021-10-08;4(5):1483-1498.

Ackr3-Venus knock-in mouse lights up brain vasculature.Ehrlich AT, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, Gross F, Hogue M, Le Gouill C, Darcq E, Bouvier M, Kieffer BLMol Brain 2021-09-28;14(1):151.

Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer.Budzinski J, Maschauer S, Kobayashi H, Couvineau P, Vogt H, Gmeiner P, Roggenhofer A, Prante O, Bouvier M, Weikert DCommun Biol 2021-09-10;4(1):1062.

Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome.Stepniewski TM, Mancini A, Ågren R, Torrens-Fontanals M, Semache M, Bouvier M, Sahlholm K, Breton B, Selent JChem Sci 2021-08-25;12(33):10990-11003.

Identifying Plasmodium falciparum receptor activation using bioluminescence resonance energy transfer (BRET)-based biosensors in HEK293 cells.Pereira PHS, Garcia CRS, Bouvier MMethods Cell Biol 2021-08-07;166:223-233.

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