Publications

Michaelis-Menten quantification of ligand signalling bias applied to the promiscuous Vasopressin V2 receptor.Heydenreich FM, Plouffe B, Rizk A, Milic D, Zhou J, Breton B, Le Gouill C, Inoue A, Bouvier M, Veprintsev DMol Pharmacol 2022-07-02.

Community guidelines for GPCR ligand bias: IUPHAR review 32.Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov KA, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, Shukla AK, Sommer ME, Gloriam DEBr J Pharmacol 2022-07-01;179(14):3651-3674.

New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans.Merali S, Wang Z, Frost C, Callejo M, Hedrick M, Hui L, Meadows Shropshire S, Xu K, Bouvier M, DeSouza MM, Yang JPlatelets 2022-06-26:1-10.

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.Priestley ES, Banville J, Deon D, Dubé L, Gagnon M, Guy J, Lapointe P, Lavallée JF, Martel A, Plamondon S, Rémillard R, Ruediger E, Tremblay F, Posy SL, Guarino VR, Richter JM, Li J, Gupta A, Vetrichelvan M, Balapragalathan TJ, Mathur A, Hua J, Callejo M, Guay J, Sum CS, Cvijic ME, Watson C, Wong P, Yang J, Bouvier M, Gordon DA, Wexler RR, Marinier AJ Med Chem 2022-06-21.

Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry.Leguay K, Decelle B, Elkholi IE, Bouvier M, Côté JF, Carréno SJ Cell Biol 2022-06-06;221(6)::e202109065.

The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites.Hedderich JB, Persechino M, Becker K, Heydenreich FM, Gutermuth T, Bouvier M, Bünemann M, Kolb PNat Commun 2022-05-10;13(1):2567.

Common coupling map advances GPCR-G protein selectivity.Hauser AS, Avet C, Normand C, Mancini A, Inoue A, Bouvier M, Gloriam DEElife 2022-03-18;11:e74107.

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.Avet C, Mancini A, Breton B, Le Gouill C, Hauser AS, Normand C, Kobayashi H, Gross F, Hogue M, Lukasheva V, St-Onge S, Carrier M, Héroux M, Morissette S, Fauman EB, Fortin JP, Schann S, Leroy X, Gloriam DE, Bouvier MElife 2022-03-18;11:e74101.

Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy E, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault E, Boudreault PL, Sarret PJ Med Chem 2022-01-13;65(1):531-551.

Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time.Duarte DA, Parreiras-E-Silva LT, Oliveira EB, Bouvier M, Costa-Neto CMHypertension 2022-01-01;79(1):115-125.

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