Publications

Functional diversity in the RAS subfamily of small GTPases.Bernal Astrain G, Nikolova M, Smith MJBiochem Soc Trans 2022-04-29;50(2):921-933.

NMR Detection Methods for Profiling RAS Nucleotide Cycling.Killoran RC, Smith MJMethods Mol Biol 2021-05-12;2262:169-182.

RAS GTPase signalling to alternative effector pathways.Singh S, Smith MJBiochem Soc Trans 2020-10-30;48(5):2241-2252.

RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway.Dhanaraman T, Singh S, Killoran RC, Singh A, Xu X, Shifman JM, Smith MJSci Signal 2020-10-13;13(653).

Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.Chang L, Yang J, Jo CH, Boland A, Zhang Z, McLaughlin SH, Abu-Thuraia A, Killoran RC, Smith MJ, Côté JF, Barford DNat Commun 2020-07-10;11(1):3464.

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith MB, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras GNat. Cell Biol. 2020-07-01;22(7):803-814.

Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel.Killoran RC, Smith MJJ. Biol. Chem. 2019-06-21;294(25):9937-9948.

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.Smith MJ, Ottoni E, Ishiyama N, Goudreault M, Haman A, Meyer C, Tucholska M, Gasmi-Seabrook G, Menezes S, Laister RC, Minden MD, Marschalek R, Gingras AC, Hoang T, Ikura MNat Commun 2017-10-23;8(1):1099.

Inhibition of RAS function through targeting an allosteric regulatory site.Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JPNat. Chem. Biol. 2017-01-01;13(1):62-68.

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith MJ, Nishikawa T, Xu Y, Neel BG, Ikura MJ. Biol. Chem. 2016-07-22;291(30):15641-52.

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