High-Throughput Screening

IRIC’s High-Throughput Screening (HTS) core facility aims to be a centre of excellence and innovation in chemical and functional screening. Designed for the use of a variety of biochemical and cell-based assays with different biological systems and models (Drosophila, C. elegans, mammalians, etc.), the core facility provides new molecular target identification as well as finding target-specific molecules in support of both fundamental and medicinal research projects.

Services offered

  • Assay optimization and validation
  • Primary and secondary screening
  • Throughput of up to 25,000 tests per day
  • Expanding chemical compound library with broad base applicability from commercial and internal sources
  • shRNA library for genome-scale screening for human or mouse
  • RNAi library for genome-scale screening for Drosophila
  • Data analysis and reporting

Our team is also available to provide guidance concerning most appropriate assay and detection methods, assay optimization and hit confirmation.

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